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Researchers at the Icahn School of Medicine at Mount Sinai have found that nearly 60 percent of the risk associated with coronary artery disease can be explained by the activity of multiple organ gene networks
Source: Courtesy of Bjork Glenn Laboratory at Mount Sinai, NY
Up to 60 percent of the risk associated with coronary artery stiffness can be explained by changes in the activity of hundreds of genes working together in a network of multiple organs in the body
"It is well known that coronary artery disease is caused by metabolic disturbances
Coronary artery disease is caused by a series of metabolic disorders that cause cholesterol and other factors to build up and block the coronary arteries
To address this question, the researchers looked at gene activity in seven different tissues in the human body
Gene activity was analyzed from the following tissue samples: blood, liver, skeletal muscle, visceral abdominal and subcutaneous fat, and two segments of arterial wall taken from different parts of the heart
"I had a hunch at the time
Gene activity was determined by measuring the levels of RNA molecules in each tissue sample
Dr.
The initial results support previous findings that the activity of individual genes in certain tissues may be associated with various cardiometabolic disorders and coronary artery disease
Instead, most risk can be explained by distinct networks of disease-related gene activity
In addition to the 20% identified in earlier studies, the current findings suggest that an additional 54-60% of the risk associated with coronary artery disease can be explained by 224 gene regulatory networks, many of which can help explain the severity of arteriosclerosis in individual cases condition
Multi-organizational networks seem to have the greatest impact
"We found that gene networks work like airplane traffic patterns
Finally, the analysis showed that hormones that help fat cells communicate with other organs, especially the liver, play a key role in coordinating the multi-organ network
Dr.
Bjorkgren's team has set up a website where researchers can test whether a candidate gene is part of these networks
.
"Ultimately, we hope this study provides researchers with the tools they need to reduce the burden of coronary artery disease worldwide," said Dr.
Bjorkgren
.
