Correct use and precautions of four-ring lyophilization experimental lyophilizer

The main components of the four-ring lyophilization experimental lyophilizer are drying chambers, codensers, refrigeration units, vacuum pumps, heating/cooling devices, etc
.

The working principle of the lyophilizer is to freeze the dried items to below the three-phase point temperature first, and then under vacuum conditions, the solid water (ice) in the articles is directly sublimated into water vapor, which is excluded from the article and the article is dried
.

After the material is pre-treated, it is sent to the quick-freezing warehouse to freeze, and then sent to the drying warehouse for sublimation and dehydration, and then packaged
in the post-processing workshop.

The vacuum system establishes low air pressure conditions for the sublimation drying chamber, the heating system provides the sublimation latent heat to the material, and the refrigeration system provides the required amount of
cold to the cold trap and drying chamber.

The lyophilizer adopts radiant heating, and the material is heated evenly; The use of water traps and rapid defrosting can be achieved; The vacuum unit is adopted, and the separation of oil and water can be realized; The use of parallel centralized refrigeration system, multi-channel on-demand cooling, stable working conditions, conducive to energy saving; Artificial intelligence control, high control accuracy, easy to
operate.

The quality requirements for lyophilized products are: unchanged biological activity, uniform appearance and luster, full form, strong structure, fast dissolution speed, and low
residual moisture.

To obtain high-quality products, there should be a comprehensive understanding
of the theory and process of lyophilization.

The lyophilization process includes three phases
: prefreeze, sublimation and relyophilization.

Four-ring lyophilization experimental lyophilizer must first understand the following precautions before use: 1, the cumulative working time of the vacuum pump reaches 200 hours or the color of the vacuum pump oil becomes brown, the vacuum pump pump oil
must be replaced.

2.
The ambient temperature and humidity of the lyophilizer should be maintained between 10 °C and 30 °C, and the relative humidity should be ≤ 80%.


3.
The distance between the lyophilizer and the wall should be greater than 30cm, and the working ring freeze-dryer should be free of conductive dust, explosive, corrosive gases and strong electromagnetic field interference
.

4.
Pay attention to the slow
ventilation of the lyophilizer.

After the micro-ventilator rotates 1/2-3/4 turns, you can feel a little bit
of your finger.

It is strictly forbidden to open the micro ventilation valve instantaneously and damage the vacuum sensor
.

5.
Do not frequently switch the main power supply and the refrigerator, and wait for 3 minutes
to start again after the refrigerator is cut off.

6.
When shutting down, it should be inflated first, and then the vacuum pump should be turned off to prevent the vacuum pump from returning oil to pollute the sample
.

7.
The plexiglass cover and the host machine are sealed with silicone sealing
rings.

The seal should be kept clean to prevent scratches and damage
.

Plexiglass covers should not be wiped
with organic solvents.

8.
After the lyophilizer is used, please wipe the cold trap moisture and the cold trap well mouth moisture clean
.