Coronavirus treatment: Which drugs may be effective against COVID-19?

!--webeditor:page"--May 1, 2020 / -- As COVID-19 continues to spread around the world, killing more than 100,000 people and paralysing the economy, doctors, scientists, and governments are looking for safe and effective treatments to help those who are sick.
, however, the big problem with COVID-19 is that so far there is no cure.
there are some treatments that can alleviate symptoms, such as breathing difficulties, but they do not address the root cause: viruses.
their idea is that treating these symptoms will help prolong the patient's life and buy time for their own immune system to start and eliminate infection.
While studies of related coronavirus over the past few decades have led to promising drugs, only large-scale clinical trials of COVID-19 patients can accurately reveal whether these interventions are safe and effective.
, such large-scale trials take time to take place, but they are under way.
World Health Organization (WHO) announced that it had helped launch four "large trials" of COVID-19 and had coordinated numerous smaller trials around the world.
: WHO-supported trials focus on drugs thought to directly block SARS-CoV-2.
SARS-CoV-2 is the strain that causes coronavirus to replicate in the lungs of PATIENT COVID-19 patients.
are some of the main drugs being studied in these trials.
, an intravenous antiviral drug used to stop infections of the coronavirus and even Ebola virus, is one of the drugs the World Health Organization is helping to investigate.
has been shown to work in laboratory dishes and in cells in mice infected with the SARS-CoV-2 virus.
redsivir is involved in making new copies of the virus specifically for key viral proteins and preventing their work.
has been used in some COVID-19 patients in the United States and appears to be safe, but large-scale trials are needed to really know if this is the case.
And on April 29th, Chinese and American scientists also published three clinical trials involving Redsivir, which showed that Redsyvir can significantly shorten a patient's recovery time, meaning that Redsyvir is by far the best known drug.
KALETRA: Lopinavir and Ritonavir, a combination of drugs used to fight HIV.
works similar to Redsyvir by blocking key viral proteins called proteases.
-Vitonave has also been shown to be effective against SARS-CoV-2 in laboratory cells and mice and is currently being tested with an antiviral drug called interferon.
is currently used to treat multiple sclerosis and can enhance the natural defenses of human cells against COVID-19.
chloroquine and hydroxychloroquine are currently used to treat malaria and the autoimmune disease lupus.
chloroquine has been used in many different infection tests because it prevents viruses (including SARS-CoV-2) from entering cells placed in petri dishes in the laboratory to prevent infection.
outside the lab, chloroquine has not yet been shown to have far-reaching effects in disease prevention, and despite Trump's hype, so far there is only limited evidence that it works for COVID-19.
, large-scale trials are still needed, and WHO supports them.
should exercise caution when using chloroquine because it has significant side effects on some people and may even block the immune response -- an ideal outcome for treating lupus.
two other options, the above-mentioned potential treatments work by using small molecules to block certain key elements of the virus infection mechanism.
two other treatments are also being tested.
the first is passive immunity, which transfers or transsections potential protective antibodies from people who have been infected with SARS-CoV-2 and have recovered from COVID-19 to high-risk groups or who are suffering from SARS-CoV-2 infection.
so-called "recovery serum" (a purified blood product for people recovering from COVID-19) can block SARS-CoV-2 in cells in laboratory dishes, potentially helping to develop treatments.
to the use of COVID-19 is being tested around the world, and so far the results appear to indicate that the treatment is safe.
: Another possible treatment is to block parts of our own immune system that may overreact to SARS-CoV-2 infections, causing damage to our lungs.
in a limited study of COVID-19, it seems that in some serious cases, our immune response is too over-reacted to remove the infection, which may increase the severity of the disease.
this happens, severe inflammation of the lungs occurs.
potential treatments are aimed at blocking the immune components associated with this severity.
that is, we must be very careful when controlling the immune response during infection, because in the absence of other treatments, we rely on our immune response to limit the replication of the virus.
, although there is currently no specific treatment for COVID-19, the drug is being tested and clinically tested and is beginning to have an effect.
this, coupled with scientists' knowledge of SARS-CoV-2, will greatly contribute to the development of a vaccine.
() Reference: 1 Coronavirus treatments: What drugs might work against COST COVID-19? The convalescent sera option for containing COVID-19 (3) This is insane! 'Many scientists lament Trump's embrace of risky malaria drugs for corona for corona !--/ewebeditor: page--!--webeditor:title="--4" Compassionate Use of Remdesivir for Patients Severe with Covid-19 (5) Wang, M., Cao R., Zhang, L. Remdesivir and chloroquine effectively resed reseded novel coronavirus (2019-nCoV) in vitro. Cell Res 30, 269-271 (2020). https://doi.org/10.1038/s41422-020-0282-0-WHO launches global megatrial of the four-most-!--/ewebeditor:page--