Coronavirus "alternative virus" or hopefully help scientists develop new therapies and vaccine strategies!

July 29, 2020 // Recently, scientists from institutions such as einstein's school of medicine have developed new research using the coronavirus "alternatives" or can help develop treatments for SARS-2-virus-using, according to a recent study published in the international journal Cell Host and Microbe entitled "Rescale A-competent vesicular for SARS-CoV-2 Spike-2 Spike-Media-Cell Entry and Itsiton." To study the potentially deadly coronavirus, researchers have turned a relatively harmless virus into a safer coronavirus "alternative" to make it safer to operate, says researcher Dr Kartik ChandranLimitations, because their research can only be done in laboratories with three biosafety cabinets installed, compared with the coronavirus "alternatives" we have developed that can be done in laboratories with secondary biosafety cabinets, whereas laboratories with secondary biosafety cabinets are more practicalPhoto Source: medicalxpress.com, a new type of coronavirus "alternative" that is a very useful system that can help accurately study how coronaviruses invade cells, as well as develop new treatments to prevent the recurrence of infections, and accelerate the speed at which researchers can assess potential treatments and vaccinesThe surface of the coronavirus is covered with a sting-like protein, which makes the virus appear to be coronal, which is why the coronavirus is named, but these stingproteins are far from mere ornaments, but the key to infection, which helps the virus seize cells and reproduce within the cell, in addition, can play a role in the coronavirus antibodies can be targeted at these stingproteinsTo develop the coronavirus "alternative", the researchers used a relatively safe virus, the herpes stomatitis virus (VSV, vesysov stomatitis virus), which is known for infecting cattle and other farm animals and causing temporary symptoms, including weakness and feverThe researchers transferred the gene that encodes the sting protein to vsV, which allows the VSV surface to germinate the sting structure, and after experiments, the researchers found that the genetically engineered VSV mimics the behavior of the real coronavirus in key waysAs the researchers did with the coronavirus, they found that the coronavirus "alternative" - VSV - can also infect human airway cells, and that VSV infections also require the presence of a special receptor of ACE2 on the cell surface, so that the stingprotein can be adsorbed to the receptor and begin the infection process, in addition, COVID-19 restores the patient's plasma antibodies can also effectively neutralizing VSVImportantly, the results show that VSV behaves very similar to real coronavirusesResearcher DrChandran said that VSV could replace real things to study how coronaviruses enter host cells and start contracting, and we are optimistic that studies using alternative viruses may explain some of the molecular mechanisms involved in coronavirus infection, which could help scientists develop new drugs that block infections and protect hosts from diseaseIn clinical trials, the researchers infuse the plasma of patients with COVID-19 infection recovery to patients with COVID-19, and to assess whether it can be used as a therapeutic means, in order to be effective, the infusion recovery plasma must contain effective neutralized coronavirusand and contain the infection of antibodies, in order to detect the presence of neutralized antibodies, the researchers combined plasma samples with VSV, and then poured the mixture into the cells in the culture, the researchers can protect the cellsResearchers are currently evaluating thousands of different antibodies in COVID-19 recovering patients to find the most effective antibodies for neutralizing coronaviruses, and the goal is to develop the best neutralizing agents into monoclonal antibodies that can be produced in large numbers to treat COVID-19 patients, and researchers are currently evaluating their ability to resist VSVWhen hundreds of antibodies were evaluated in this way, the researchers found several very effective antibodies, and they hope that scientists will be able to identify antibodies as therapies through joint research, as there is an urgent need for researchers to develop new treatments for COVID-19 infectionIn addition, "alternatives" to coronaviruses appear to have other uses, and with the progress of TESTing for the COVID-19 vaccine, there is an urgent need for researchers to test them in secondary biological laboratories to assess the immune response of these vaccines in animal models and human bodies() Photo: "1) Corona Mayvirus help researchers sdiscover therapies and vaccines 2 MEugenia Dieterle, Denise Haslwanter, Robert HBortz, et al A-dra-competent vesvie stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition, Cell Host and Microbe (2020) doi: 10.1016/j.chom.2020.06.020.