Cornea: Antihistamine release contact lenses can be used to treat allergic itching in the eyes.

In this study, two multi-center, randomized, placebo-controlled tests tested an antihistamine tetyfen drug delivery system based on contact lenses (CL).
the test lenses were ethyl noncon A containing 0.019 mg of ketoticin;
subjects were randomly divided into 3 treatment groups.
the first set of one-eyed test lenses and the side-eye control lenses, and randomly selected the eyes of the test lenses at a 1:1 scale.
the test lenses in the second group of eyes and the control lenses in the third group.
allergen challenge was performed in 2 separate follow-up visits: after wearing glasses, the subjects were tested for 15 minutes (the start of the test) and 12 hours (for the duration of the test).
end point is itching of the eyes measured using a scale of 0 to 4 half-unit steps.
secondary endpoints include lashes, conjunctivitis and epidural highemia.
results showed that the average itching score of the eyes wearing the test lenses was lower than that of the eyes wearing the control lenses, indicating that the test lenses effectively reduced allergic reactions.
the two trials, the average difference in itching was statistically and clinically significant in both incidence and duration (average difference of 1).
, this large-scale assessment (n - 244) is the first to demonstrate the efficacy of CL delivery in treating eye allergies.
results are comparable to direct local dosing and indicate that the lens/ketotine combination can provide the CL wearer with the means to correct vision and treat eye allergies at the same time.
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