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College of Food Science and Technology, Huazhong Agricultural University
Huang Qian, female, Ph.
Title
Study on promoting calcium absorption and mineralization of phosphopeptide of yolk protein
Summary
The osteoblast model was constructed and it was found that the phosphorylation degree of phosvitin (PV) is a key factor to promote the proliferation and mineralization of osteoblasts.
On this basis, it has been explored that temperature and pressure cooperative pretreatment, combined with protease complex enzymatic hydrolysis, can significantly improve the efficiency of PV hydrolysis while avoiding the loss of phosphate groups.
The number of enzymatic hydrolysis fragments has been increased from 34 to 280, realizing PV deep enzymatic hydrolysis.
It provides a rich peptide resource library for the later screening of high-activity calcium-affinity peptides
.
Established a low-calcium diet mouse model, evaluated the effects of PV and phosphopeptides on calcium absorption and bone formation, and explored their pathways of action
.
Construct models of osteoblasts, osteoclasts and cell co-cultivation, explore the effects of phosphopeptides on the proliferation, differentiation, mineralization or apoptosis of osteoblasts MC3T3-E1 cells and osteoclasts RAW264.
7, and clarify their effects.
The mechanism of promoting the proliferation of osteoblasts and inhibiting the differentiation of osteoclasts
.
