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Comprehensive genetic study of cleft lip and palate

 Last Update: 2021-08-05
 Source: Internet
 Author: User

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Researchers at the Institute of Human Genetics at Bonn University Hospital have combined various data sources in their work

Ludwig led a junior research team called Emmy Noether at the Institute of Human Genetics at Bonn University Hospital, which focused on the genetic causes of cleft lip and palate

Combine data from previously published genome research

Each person’s blueprint is stored in his or her DNA, which is a huge vocabulary of approximately 3 billion letters

In recent years, a series of such "genome-wide association studies" (GWAS) have been published

However, this does not automatically contribute to a better understanding of the disease: only about 2% of DNA actually contains genetic information, the direct instructions for building proteins

It is now known that part of non-coding DNA is used to regulate gene activity

Mutations affect regulatory DNA elements

In each cell, only certain genes are active during certain developmental periods

Presumably, each of the 45 risk zones known today will change the effect of the enhancer or silencer

Journal Reference :

Julia Welzenbach, Nigel L.

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