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Comprehensive control of Pseudomonas metabolic state by modulating the polyhydroxyalkanoate cycle

 Last Update: 2022-02-22
 Source: Internet
 Author: User

Summary

Polyhydroxyalkanoates (PHAs) are polyesters produced by a variety of microorganisms for energy and carbon storage

The simultaneous synthesis and degradation of PHA drives a dynamic cycle associated with central carbon metabolism that regulates a number of diverse bacterial processes such as stress tolerance, pathogenesis, and persistence

Although a great deal of research has been devoted to understandingPseudomonasApart from the roles of key regulatory players, the metabolic basis underpinning the dynamic control of their biological fitness under perturbed conditions remains largely unknown

PseudomonasConsists of a large number of Gram-negative aerobic gamma-proteobacteria (1).

Pseudomonas putidaA model of the "worldwide bacteria" known for its robust metabolism and ability to withstand stress (13–15).

twenty one,twenty two) granules are encapsulated by granule-associated proteins (GAPs) involved in PHA metabolism and regulation, namely polymerases, depolymerases, phase proteins and other proteins with similar functions (23–26).

A critical gap mediating the PHA cycle

Pseudomonashighlighted the role of PHA metabolism in the evolutionary success of this important bacterial genus (6).

PseudomonasIn this work, we evaluate the PHA loop as a robust loop inP.
stenchKT2440
.
This requires a multidisciplinary approach involving systems and synthetic biology to modulate carbon flux in the PHA cycle by regulating the flux of the PHA reaction
.
We also provide solid evidence that the PHA cycle plays a key metabolic role in inducing carbon flux rerouting, such as oxidative stress
.

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