Comparison of the extended survival of LGG patients with single chemotherapy or radiotherapy

Low-grade glioma (LGG) is a class of immersive primary brain tumors, including WHO II-grade astrocyma, less protogloutocell tumor, and less protoscopic atomcell tumorCurrently, the standard treatment for LGG patients is to surgically remove tumors to the maximum extent possible within a safe rangeFor patients not suitable for surgical removal, chemotherapy, radiotherapy, or combination therapyRadiotherapy and chemotherapy combined treatment are becoming more and more commonHowever, the relationship between radiotherapy or chemotherapy and total survival (OS) in patients with LGG is unclear without surgical resectionJing Wu of Xiangya Hospital, Hunan Province, and others reviewed the effects of single radiotherapy or single chemotherapy to treat low-level gliomas through literature review, which was published online in World Neurosurgery in September 2018the authors retrieved patients who were not surgically removed between 2004 and 2013 in the National Cancer Database (NCDB) but were hetologically diagnosed as Grade II gliomasThe total survival of single radiotherapy or single chemotherapy patients was compared using Kaplan-Meier analysis, multi-factor Cox regression, and tendency scoring matchingthe study included 1,126 patients with stage II glioma, including 715 (63.5%) for single radiotherapy and 411 (36.5%) for single chemotherapyCompared with single radiotherapy, single chemotherapy can significantly extend the total survival of patientsFactors such as the patient's age of 60 years, from diagnosis to radiotherapy or chemotherapy intervals of 30 days, were associated with a longer total lifetimeAn analysis of patients in different age groups found that single chemotherapy had the advantage of extending survival compared to single radiotherapy in both the 60-year-old group and the 60-year-old groupFor different histological types of gliomas, single chemotherapy prolonged the total survival of patients with astrocyte tumors and less protoplacytes, while the efficacy of less protocytosis was not obviousanalysis showed that single chemotherapy had an advantage over single radiotherapy in extending the total survival of LGG patients without surgical resection, and that single chemotherapy or radiotherapy had different effects on the total survival of patients with gliomas of different ages and different histological types.