Comparison of prognosis between GBM ultra-total excision and total excision patients in non-functional area

In a single-center retrospective study of non-functional GBM surgery, Tae Hoon Roh of Yonsei University in Seoul, South Korea, and others assessed whether SupTR had a longer survival period compared to GTR without normal tissue during tumor weeksThe results were published online in March 2019 by Journal of The Economist- Excerpted from the article chapter
(Ref: Roh TH, et alJ Neurosurg2019 Mar 1:1-7doi: 10.3171/2018.12.JNS182558The common surgical methodglioblastoma (GBM) is to completely excision (gross-total resection, GTR) along the gumalic belt around the tumor, but residual cells that are not visible to the naked eye around the tumor can easily cause the tumor to recurTherefore, some neurosurgeons have proposed extended excision in non-functional lines (supratotal resection, SupTR), i.eultra-total excision of the tumorHowever, it is not known whether normal tissue during SupTR weeks can improve survival rates in GBM patientsIn a single-center retrospective study of non-functional GBM surgery, Tae Hoon Roh of Yonsei University in Seoul, South Korea, and others assessed whether SupTR had a longer survival period compared to GTR without normal tissue during tumor weeksThe results were published online in March 2019 by Journal of The Economistthe researchers retrospectively analyzed data from 40 idh-wild GBM patients with tumors in the frontal lobe or temporal lobe, 20 in the ultra-total excision group (SupTR group) and 20 cases in the full excision group (GTR group) according to the scope of tumor removalComparing progress-free survival (Progression-Free Survival, PFS), overall lifetime (Overall Survival, OS) and Karnofsky score (Karnofsky Performance Score, KPS) with a significant difference of p.05results showed that the median PFS in the GTR group was 11.5 months (95% CI, 8.8-14.2) and the SupTR group was 30.7 months (95% CI, 4.3-57.1), with significant differences (p-0.007) The median postoperative OS in the GTR group was 18.7 months (95% CI, 14.3-23.1), the SupTR group was 44.1 months (95% CI, 25.1-63.1), with significant differences (p.0.040); The multivariate analysis shows that the PFS and OS in the SupTR group are better than the GTR group, with HR of 0.230, 95% CI, 0.090-0.583 (p-0.002) and HR-0.247;95% CI,0.086-0.004 (p-0.009) (Table 1, Figure 1), respectively for non-functional GBM patients, hypertotal removal of tumors provides a better prognosis, both PFS and OS are extended, and do not negatively affect patient clinical performance table 1 Clinical data sheet for 40 non-functional GBM patients Figure 1 No progression and total survival (OS) in patients in the SupTR group and GTR group postoperatively Bit PFS in A.GTR group is 11.5 months (95% CI, 8.8-14.2) and supTR bit PFS is 30.7 months (95% CI, 4.3-57.1; p-0.007); The bit OS in the .GTR group was 18.7 months (95% CI, 14.3-23.1) and the supTR group's bitos were 44.1 months (95% CI, 25.1-63.1; p.040).