Comp Biochem Physiol C Toxicol Pharmacolol: Effect of titanium dioxide nanoparticles on the cell response of macrophages
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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As the most widely used nanomaterial in biology and medicine, it is necessary to explore the interaction between titanium nanomaterials and biological systems and subsequent cellular reactionsHere, the combined state of two TiO2 nanoparticles in the medium was characterized, and cluster-specific cell response in RAW264.7 cells was studied21 nm of TiO2 NPs exhibits higher cytotoxicity due to smaller aggregates and positively charged surfaces, which is related to their ability to cause damage to mitochondriaFor 35 nm TiO2 NPs, higher levels of autophagy and stronger inflammatory immune responses were observed, which is the cause of their lower cytotoxicity, these results show that the physical and chemical properties of TiO2 NPs in the medium are important factors affecting their response to RAW264.7 cells
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