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Tau is a microtubule-associated protein, mainly found in neurons.
Microglia can take up and release tau.
pixabay
pixabayDuring the development and progression of Alzheimer's disease, a protein called tau accumulates and spreads in the brain.
prevention
Recently, the Massachusetts General Hospital (MGH) research team confirmed that it involved an anesthetic that is known to affect cognitive function.
The team developed a new method to measure tau levels, called nanobeam sensor technology.
The team conducted experiments in mice and cells, evaluating mice and neurons treated with the anesthetics sevoflurane and desflurane.
Studies have found that sevoflurane increases the amount of tau or p-tau in blood, neuronal culture fluid or EVs, and increases the amount of p-tau in the brain interstitium.
Research results show that the transport of tau occurs from neurons to microglia, producing IL-6, leading to cognitive impairment.
The transport of tau occurs from neurons to microglia, producing IL-6, leading to cognitive impairment.
Neuronal media conditioned by sevoflurane induces the appearance of tau and p-tau in tau KO microglia
Neuronal media conditioned by sevoflurane induces the appearance of tau and p-tau in tau KO microgliaSevoflurane increases the amount of extracellular IL-6 in the culture medium of neurons and microglia
Sevoflurane increases the amount of extracellular IL-6 in the culture medium of neurons and microgliaCo-first author Yuanlin Dong, MD, a researcher in the department, said that this finding shows that neuronal cell membranes and cell viability are not damaged by sevoflurane treatment.
Original source:
Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E.
The anesthetic sevoflurane induces tau trafficking from neurons to microglia Communications Biology 10.
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