Commonly used intravenous anesthetic propofol may increase the risk of tumor invasion and metastasis

China News Service, July 16th (Chen Jing and Yang Jing) The influence of anesthetics on patients' brain function and tumor recurrence and metastasis has been controversial for a long time
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The reporter learned on the 16th that Professor Yuan Shen, Director of the Department of Psychiatry, Shanghai Tenth People’s Hospital and Executive Deputy Director of the Institute of Anesthesia and Brain Function, Tongji University School of Medicine, and Professor Xie Zhongcong, Director of the Geriatric Anesthesia Laboratory, Harvard University Massachusetts General Hospital After two years of exploratory research, the team has confirmed from multiple levels that the commonly used intravenous anesthetic propofol may increase the risk of tumor invasion and metastasis
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In previous cytotoxicological experiments, researchers observed that propofol, a widely used intravenous anesthetic in clinical practice, can significantly increase the adhesion of tumor cells to the vascular endothelium
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According to reports, circulating tumor cells (CTCs) are considered to be the main factor for tumor metastasis and recurrence after surgery, and the adhesion of circulating tumor cells and vascular endothelial cells can promote tumor cells to break through blood vessels and invade into tissues
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What kind of interaction exists between anesthesia, tumors and brain function? With a series of questions, the researchers started a two-year exploration
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The research team also proved the mechanism of propofol's effect on promoting tumor cell adhesion and extension through research
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Next, the researchers used the same in vitro pretreatment method to observe more tumor cells, including lung cancer, endometrial cancer cells, etc.
, and found that propofol can make more tumor cells adhere to vascular endothelial cells compared to the control group , And accompanied by a larger extension area and more adhesion spots formation
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Based on this, the researchers have further locked the important target for the development of anti-cancer drugs, and at the same time an important proto-oncogene-Src kinase that mediates cell adhesion
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It is understood that the Shenyuan team has continued to explore in the field of anesthesia, tumors and brain function in recent years, and initially discovered the mutual influence of anesthesia, AD and other diseases with the occurrence and development of tumors
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