Commin Biol: new research reveals early plaque formation in Alzheimer's disease

October 8, 2019 news / BIOON / -- long before memory loss and other symptoms, Alzheimer's disease patients have pathological changes in the brain, such as accumulation of amyloid plaques Recently, a new study from MIT neuroscientists has proposed new insights into the accumulation mechanism of amyloid plates in the mouse brain The study also showed that the accumulation of amyloid protein in the relevant areas of the human brain was closely related to the deterioration of the disease "Alzheimer's is a neurodegenerative disease that eventually leads to a large number of neuron loss," said wennqin Huang, a postdoctoral fellow at Li Huei, co-author of the study By then, the symptoms will be hard to cure It will promote the development of related therapies to understand the abnormal areas of neurons in the brain in the early stage of disease " (image source: www Pixabay Com) in recent years, many research groups have used positron emission tomography to track the accumulation of amyloid protein in the brain, but this new study can accurately observe the whole brain of mice for about one month The study showed that amyloid began to spread in deep brain areas such as the papillary body, lateral septum and hypothalamus, then along specific brain circuits into the hippocampus (the key area of memory) and cortex The team used the technology switch developed by Chung to label amyloid plaques and figure out the whole brain of 5xfad mice so that they can be finely imaged at different ages The team was able to see plaques first appear in the deep structure of the brain and then spread throughout the brain within six to 12 months "This study provides a basis for further study of how these brain regions and circuits dysfunction can cause symptoms of Alzheimer's disease," the authors said Research pinpoints Alzheimer's plan emergency early and deep in the brain original sources: Rebecca Gail canter, Wen chin Huang, Heejin Choi, Jun Wang, Lauren Ashley Watson, Christine g Yao, fatema abdurob, Stephanie M bousleiman, Jenny Z young, David A Bennett, Ivana delale, kwanghun Chung, Li-Huei Tsai 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice Communications Biology , 2019; 2 (1) DOI: 10.1038/s42003-019-0599-8