Combined with antibiotics, the researchers gave the ubiquitous bacteria a blow

By first combining two mature antibiotics, a scientific team led by case-based Case Western Reserve University School of Medicine and The Va Medical Center in Cleveland, Louisiana, "double wreccuped" the ubiquitous pseudomonasaeruginosa, a potentially deadly bacteria and a major source of hospital infections.
In a recent study in the journal Infectious Diseases, researchers showed that copper-green protobacteria in P. mouse models were significantly more effective than antibiotics alone. Antibiotics are a combination of cephalosporine-avithromycin, which is used to treat a variety of serious bacterial infections, and phosphromycin, which is mainly used to treat urinary tract infections.
“ By successfully combining these two drugs with this widespread bacteria, we hope to lay the groundwork for the eventual eradication of infection," said Krisztina M., lead author of the study. Dr. Papp-Wallace, an assistant professor of medicine at the Medical School and a research scientist at the VA Medical Center in Cleveland, said the findings are important for further research into clinical applications and benefit many patients around the world.
Patients with low immune function, such as those with cancer or cystic fibrosis, burn victims and those on ventilators, are particularly vulnerable to bacteria that can be transmitted by health care workers or contaminated equipment.
Bacteria and other microorganisms are becoming more resistant to antibiotics, making infections difficult to treat and increasing the risk of contamination of others. As a result, health care costs are also increasing. Sometimes, microbes that produce antimicrobial resistance are called "superbugs". Although this resistance usually occurs naturally over time, usually through spontaneous genetic changes, the abuse and overuse of antibiotics in humans and animals is accelerating the process.
The new method described in this paper is designed to destroy enzymes in the walls of bacterial cells. Look for specific P strains. The copper-green dubio monocytobacteria, known as CL232, found that after 24 hours, treatment with a combination of cephalosporine-avithromycin-phosphromycin was more effective at reducing bacterial presence than using drugs alone.
“ Dr. Papp-Wallace's insight into combining the two antibiotics proved correct," said Robert A., senior author of the study. Bonomo, M.D., professor of medicine, pharmacology, molecular biology and microbiology at the University of California, Cleveland VA Medical Center, says it's an excellent bedside-to-bed science that has positive implications for future patients around the world. (Compiled by this web)