Colonoscopy should be done at the age of 45! The Stanford team analyzed the big data of 6 million people and found that the first colonoscopy between the ages of 45-49 is associated with a 50% reduction in the risk of colorectal cancer | Clinical Discovery

To talk about medical examinations and tests that make ordinary people "fearful", then gastroscopy colonoscopy is definitely on the list.
Singularity cakes are often privately chatted by anxious friends, asking if it is really necessary to have an examination? The answer to singularity cake usually has only one word: do.

In order to eliminate colorectal cancer in its embryonic stage, it is quite cost-effective to pay the price of discomfort every few years.
Otherwise, it is just as positive as the third largest cancer in the world? Let's not do business that is losing money.

The global incidence of new bowel cancers is second only to breast and lung cancer (Image source: Johns Hopkins University) A recent analysis by the Stanford University team shows that the start of colonoscopy may be 50 years old Downgrade to 45 years old: Compared with 45-49 years old who do not receive colonoscopy, receiving colonoscopy during this period is related to a 50% reduction in the risk of colorectal cancer! The research team used the research data of more than 6 million residents in Florida, USA, and discovered the great effect of early colonoscopy.

Colorectal endoscopy at the age of 50-54 is related to a 68% relative decrease in the risk of colorectal cancer, but it is certainly better to find colorectal cancer early [1].

The research is published in Gastroenterology.

The widespread development of colonoscopy has contributed to reducing the incidence of colorectal cancer in European and American countries.
The latest data released by the American Cancer Society last year showed that the proportion of colonoscopy among adults over 50 in 50 states in the United States exceeded 60%.
[2], it is unique in the world.

It is said that the proportion of colonoscopy in the United States is 5-6 times that of China, but it is hard to say whether it can reach 10% in China (picture source: Mayo Clinic), but the latest 2020 Global Cancer Statistics Report (GLOBOCAN) pointed out that although 50 years old The above-mentioned decline in the incidence of colorectal cancer is very gratifying, but at the same time, affected by factors such as obesity, dietary patterns, and lifestyles, the incidence of colorectal cancer under the age of 50 is rising rapidly in many countries [3].

If you continue to set the threshold for colonoscopy at the age of 50, many patients may be missed.
Therefore, the American Cancer Society took the lead in adjusting the guidelines in 2018.
It is recommended that people at general risk of colorectal cancer also start colonoscopy at the age of 45.
But other authoritative guides and societies did not immediately follow up.

Whether 50 years old is appropriate or 45 years old is better, this kind of problem definitely cannot be used in clinical trials, so we have to look at cohort studies with very large samples.

This time, the Stanford team selected Florida, which has a large population, complex ethnicity, and colonoscopy results that are legally reported and archived, and collected data from 2005 to 2016 for analysis.

The population analyzed in the study can be divided into two groups and four parts.
The first group is 195,000 people aged 45-49 who have undergone colonoscopy, and 2.
57 million people who have not undergone colonoscopy during the same period (the same below) Compare the incidence of bowel cancer; the second group is 660,000 people aged 50-54 who have undergone colonoscopy, compared with 2.
43 million people who have not undergone colonoscopy.

The legal reporting of colonoscopy results can minimize missed diagnosis and treatment (picture source: University of Michigan).
From the purpose of the examination, 31.
7% of the 45-49-year-old colonoscopy population is due to gastrointestinal bleeding, anemia, etc.
Symptoms were checked.
Among the 50-54-year-old population, this proportion was only 10.
2%.
The proportions of screening colonoscopy in the two groups were 19.
7% and 55.
3%, respectively.

The incidence of colorectal cancer during the follow-up period in each group is as follows.
After adjusting for various related factors such as age and gender, colonoscopy for the first time at the age of 45-49 is related to a relative decrease in the incidence of colorectal cancer in the population by 50% (HR = 0.
50) ), and 50-54 years old is associated with a relative decrease of 68% (HR=0.
32).

The specific incidence and incidence of colorectal cancer in people aged 45-49 and 50-54, although only looking at the HR values ​​of the two groups, colonoscopy at the age of 50-54 seems to be more effective, but the research team clearly pointed out in the paper The screening age cannot be calculated by only looking at the HR value, and among the 45-49-year-old people who are tested, the proportion of people who are tested for suspected colorectal cancer symptoms is higher, which means that people at higher risk may get colonoscopy earlier.

In the analysis of people aged 45-49 who did not undergo colonoscopy, the incidence of bowel cancer during the follow-up period was about 30 cases per 100,000 people, and the incidence rate was not low.
The promotion of colonoscopy screening should be cost-effective.
(Cost-effectiveness).

Soon after the publication of this paper, the American College of Gastroenterology (ACG) released the latest 2021 colorectal cancer screening guidelines, which conditionally recommends that people at general risk of colorectal cancer start screening at the age of 45-49[4], It seems that the younger generation of colonoscopy is also the general trend.

Moreover, it must be emphasized that China's colorectal cancer screening is far from enough, especially for middle-aged and elderly people who are at a high-risk period.

It is said that cancer should be diagnosed and treated early, so everyone has to do colonoscopy? Wait until the symptoms appear, and then see a doctor, it's usually too late.

Singularity is hiring everyone! Everybody Hi~! Let today’s duty cakes replace all the singular cakes and shout out: Let’s order new cakes! Singularity has been with you for six years.
The days of chasing the updates of scientific research journals are passing very fast.
The singularity cakes have grown in knowledge and have less hair.
.
.
These years we have experienced immunotherapy, gene editing, artificial intelligence, etc.
The new technology has shown its brilliance, and we have seen more scholars working step by step under historical problems such as cancer, cardiovascular disease, Alzheimer's disease, and diabetes.

There are good studies cheering and shouting, and when the update is not effective, scientists are scolded for not working hard.

Write every day and update every day.
Now we have more than 2,000 original articles! To say that writing is the happiest, but it was turned over by the author of the paper.

The duty cake was praised by a big cow scholar about the key points, accurate interpretation, witty and easy to understand, and was also asked by the big guy if it was a professional eloquent writer.
The feeling at the time was really awesome.
(Akimbo.
jpg).

Now, we are going to try to explore new boundaries.

There are limits to the expressive ability of words, and the breadth and splendor of scientific research deserve to be known to everyone in more forms.

Next, we are going to try to contain the frontiers of science with video, so that everyone can sigh the beauty of life from different angles; at the same time, text is still our sharpest weapon, interesting, vivid and professional articles will go on and on and on.
.
.
.
.
.
We need fresh blood to inject new energy into the singularity.

Come on, become the singularity cake and do a new job with us! These are the little friends we are currently looking for~ If you want to create and innovate with the singularity cakes, come join us.

Please send your resume and works (if any) to: hr@geekheal.
com We are waiting for you at Singularity.  References: 1.
Sehgal M, Ladabaum U, Mithal A, et al.
Colorectal Cancer Incidence After Colonoscopy at Ages 45–49 or 50–54 Years[J].
Gastroenterology, 2021.
2.
American Cancer Society.
Colorectal Cancer Facts & Figures 2020 -2022.
Atlanta: American Cancer Society; 2020.
3.
Sung H, Ferlay J, Siegel RL, et al.
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].
CA: A Cancer Journal for Clinicians, 2021.
4.
Shaukat A, Kahi CJ, Burke CA, et al.
ACG Clinical Guidelines: Colorectal Cancer Screening 2021[J].
The American Journal of Gastroenterology, 2021, 116(3): 458-479.
Source: Wikipedia Author of this article | Tan Shuo