Collection: Selected by BMJ Research on February 1, 2020

1Smoking during pregnancy increases the risk of fractures in future generationsdoi: https://doi.org/10.1136/bmj.l7057researchers recently looked at the relationship between smoking during pregnancy and the risk of fractures in offspringaverage follow-up of 21.1 years, with a total of 377,970 fractures and 11.8 fractures per 1,000 participants per yearThe relationship between mother smoking during pregnancy and the risk of fractures in future generations varied according to age: smoking in early pregnancy led to an increased risk of fractures before the age of one year, 1.59 fractures per 1,000 participants in tobacco exposure, 1.28 cases in the unexposed population, and an adjusted risk ratio of 1.27Increased risk was associated with tobacco exposure, with 1-9 smoking and 10 or more mothers' offspring at 1.20 and 1.41, respectively, compared to non-smoking mothersSmoking during pregnancy increases the risk of fractures in offspring 5-32 years of age, but these associations do not follow dose dependence, fermented soy products can reduce the risk of death
doi: https://doi.org/10.1136/bmj.m34recently researchers looked at the relationship between edible soybean products and the risk of whole-cause and specific deathstudy was conducted in Japan, with 92,915 volunteers aged 45-75 participating in the study, which followed 13,303 participants over 14.8 yearsAfter multi-factor adjustment, there was no significant correlation between total soy product intake and total mortalityCompared to the lowest 1/5 population intake of total soy products, the highest 1/5 risk of death was 0.98 for men and 0.98 for womenThe intake of fermented soy products was negatively correlated with the mortality rate of both sexes, with the highest risk of death being 0.90 for men and 0.89 for women compared to the population with the lowest intake of 1/5Natto reduces the risk of death associated with general cardiovascular diseases : The of opioid prescription use in the United States from 2003 to 2017: https://doi.org/10.1136/bmj.l6968 researchers recently looked at opioid use in 50 U.S states and Washington, D.C averaged 669,495 medical facilities in the United States from 2003 to 2017 wrote 8.9 million opioid prescriptions to 3.9 million patients each year The main endpoints of the study were standardized morphine equivalents (MMEs) and the number of opioid prescriptions for opioids In 2017, the top 1% of medical institutions prescribed opioid prescriptions at 49% of the total dose and 27% of the total prescriptions In absolute terms, the prescription dose of the top 1% of the above organs is 748,000 MME - 1,000 times the average dose Of the 1 per cent mentioned above, about 50 per cent can still enter up to 1 per cent in neighbouring years About 40% of prescriptions with an average daily dose of more than 50MME and more than 80% of prescriptions for more than 7 days are issued by the above-mentioned 1% agency, while in the other 99% of medical institutions, 86% of the daily average prescription dose is less than 50MME for less than 7 days The institutions prescribing large doses of opioids and patients receiving high-dose opioids are long-term, with more than half of them occurring in neighbouring years MedSci Source: MedSci Original