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The findings provide a solid basis
for further research into nicotine withdrawal behavior.
Some smokers find that their first cigarette of the day is less pleasant without a cup of coffee
.
In a cell-based study, researchers found that two compounds in coffee directly affect certain highly sensitive nicotine receptors
in the brain.
Dr.
"Many people like to drink coffee in the morning, but other molecules in coffee may explain why smokers want to drink coffee," Papke said
.
The researchers applied a deep-roasted coffee solution to cells
expressing a specific human nicotine receptor.
The findings led Papke to a broader hypothesis: A compound in brewed coffee called n-MP may help reduce morning nicotine cravings
.
Papke said he was intrigued
by the idea that nicotine dependents associate smoking with drinking coffee in the morning and drinking alcohol in the evening.
"Many people drink coffee in the morning because coffee contains caffeine
.
The findings, he said, provide a good basis for behavioral scientists to further study nicotine withdrawal
in animal models.
Reference: Coffee and cigarettes: Modulation of high and low sensitivity α4β2 nicotinic acetylcholine receptors by n-MP, a biomarker of coffee consumption
