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Clinical trial of Garcos KRAS G12C inhibitor in combination with cetuximab approved in China

 Last Update: 2022-02-24
 Source: Internet
 Author: User

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On December 3, the combination trial of JAB-21822, a KRAS G12C inhibitor independently developed by Jiakesi, and cetuximab injection was approved by the CDE

Garcos to initiate a Phase I/II, open-label, multicenter, dose-escalation and expansion clinical study in China to explore the safety of JAB-21822 in combination with cetuximab in patients with KRAS G12C-mutated advanced colorectal cancer Sex, tolerability and preliminary efficacy

JAB-21822 combined with cetuximab can enhance the anti-tumor activity of JAB-21822 inhibitor in colorectal cancer tumor model, make the tumor regress, and delay the tumor recurrence after drug withdrawal.

JAB-21822 R&D progress of JAXIS

JAB-21822 has been approved for 5 clinical trials in China and the United States, including single drug trials and combination trials with PD-1 monoclonal antibody or cetuximab, respectively.

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