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Clinical trial of CAR-T cell therapy ATA2271 suspended due to patient death

 Last Update: 2022-03-05
 Source: Internet
 Author: User

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Biopharmaceutical company Atara Biotherapeutics said Friday that a phase I trial of its autologous mesothelin-targeted CAR-T cell therapy ATA2271 has been suspended due to fatal serious adverse events (SAEs) in participants treated in the study.

.

The experimental therapy is currently in clinical studies in patients with malignant pleural mesothelioma

CAR-T

The MSK Phase I clinical study enrolled 27 patients, 25 with malignant pleural mesothelioma (MPM), 1 with metastatic lung cancer , and 1 with metastatic breast cancer , who had received 3 prior treatment regimens , The purpose of this study was to evaluate the safety and potential antitumor activity of mesothelin-targeted autologous CAR-T cell therapy
.

The study added two higher-dose cohorts, administered directly to the tumor site, to the 6-dose cohort reported in March 2019

lung cancer breast cancer

Pleural mesothelioma (MPM) is a primary tumor derived from pleural mesothelial cells and accounts for 5% of pleural tumors
.

Pleural mesothelioma can occur in any part of the visceral and parietal pleura, with 80% occurring in the visceral pleura and 20% in the parietal pleura

According to Atara, the deceased had a history of multiple malignancies and other comorbidities, and the patient was being treated for advanced, recurrent mesothelioma
.

The first six participants in the trial's two lowest-dose cohorts received either ^1x106 cells/kg or 3x106 cells/kg intrapleural ATA2271 and there were no dose-limiting toxicities, ^the

⁶⁶According to Atara, the patient who died was the first patient to receive the high-dose cohort of 6x10 ⁶ cells/kg

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