Clinica Chimica Acta: What is the diagnostic value of the free-frisk light chain?

The detection of the oligoclonal band (OCB) in cerebrospinal fluid (CSF) is the gold standard fordiagnosis of inflammation in theHowever, the significance of an isolated strip in The CSF is uncertainFree light chain kappa (FLC-k) as an auxiliary method to detect intrauterine inflammation, has attracted more and more attentionThe purpose of this study was to explore the performance of FLC-k in patients with a single separation zone in cerebrospinal fluidresearchers used Siemens FLC-k kits to analyze cerebrospinal fluid and serum in 56 patients with electric focus such as isolated bandsAccording to the medical diagnosis, the samples were divided into inflammatory nervous system disease group, non-inflammatory nervous system disease group and symptom groupThe FLC-k score is represented in the FLC-k quotient chartThe OCB interpretation is done by three experienced scorers blindof 6,695 OCB analyses, 91 (1.4%) had an isolated band in cerebrospinal fluidThis study excluded patient samples and sample availability re-evaluated due to unclear OCB patterns and included 56 patient samplesThe FLC-k value of all patients with inflammatory diseases (n s 13) was higher than the distinguished line (Qlim) on the FLC-k quotient graph, with a sensitivity of 100%, a positive prediction of 52%, and a negative predictor of 100%The FLC-k value was higher than Qlim in 14 (36%) non-inflammatory diseases (n s 39)results have shown that the lack of FLC-k in patients with an isolated band in cerebrospinal fluid strongly promotes the non-inflammatory origin of the diseaseThe implementation of FLC-k measurements can help clinicians diagnose neurological disorders