Clinica Chimica Acta: Study on the ratio of albumin to fibrinogen, c-reactive protein and albumin ratio to Th17 cells in patients with rheumatoid arthritis

Albumin-fibroprotein-in-figen ratio(AFR)andcreactive protein-to-albumin ratio(CAR)are often used as markers of inflammationHowever, their role inRAremains unclearWe studied the relationship betweenAFR/CARinRAand the concentration of autoantibodies andTh17cell concentrationsthis study was included in 196cases ofRApatients,200patients with systemic lupus(SLE)andcases of healthy donor(HD)in the first affiliated hospital of Fujian Medical UniversityThe researchers reviewed the results ofFIB, ALB , CRP , anticyclic peptide antibody (anti-CCP) , rheumatine factor (RF) , and blood (ESR) in RA patients and SLE patients The flow cytometer detects the percent content of peripheral blood Th17 cells in patients RA , RT-qPCR detects the relative expression of TNF-alpha , IL-6 and IL-17A Correlation analysis of AFR/CAR and Th17 cells in RA , CRP , ESR , TNF-alpha , IL-6 and IL-17A results show that the percentage of peripheral blood Th17 cells in patients with RA decreased significantly compared to patients with SLE and healthy donors (
HD ), the concentration of AFR in patients with RA decreased significantly (
P 0.01 ), while the concentration of CAR in patients with RA increased significantly (
.01 ) AFR and CRP (
r - .7103 ), ESR (
r ? -0.6542 ), RF (
-0.2219 ), Th17 cells (
r s .5952 ) and IL-17A (
.468 1) CAR with CRP (
r 0.9899 ), ESR (
r s 0.605 ), RF (
0.1867 ), Th17 cells (
r s 0.6818 ), TNF-alpha (
r s 0.3388 ) and -1 70 as a result, the results of the results show edify a decrease in the concentration of CAR in patients with ra
AFR AFR and CAR are associated with CRP , ESR , RF , and Th17 cell ratios in patients with RA and can be used as a potential indicator of inflammation in RA