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Clin Nutrition: The bioavailableness of 25 (OH)D was associated with clinical outcomes in patients with diffuse large B-cell lymphoma

 Last Update: 2021-01-12
 Source: Internet
 Author: User

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We already know that vitamin D deficiency is associated with poor clinical outcomes for many types of cancer.
, its role in patients with diffuse large B-cell lymphoma (DLBCL) remains unclear.
study, the researchers aimed to determine the role of total circulatory 25 (OH) D and bio-utilization 25 (OH)D levels in DLBCL patients in determining disease prognostication.
researchers recruited a total of 332 newly diagnosed DLBCL patients.
the total plasma 25 (OH) D and Bioutability 25 (OH) D levels at the time of diagnosis and assessed their relationship to clinical characteristics and patient prognosis.
also assessed the clinical characteristics and truncation values of 25 (OH)D levels in DLBCL patients' response to chemotherapy (R-CHOP).
92.8 percent of the patients in this study had insufficient vitamin D status.
25 (OH)D patients with higher bioutability of plasma had better disease progression-free lifetimes (HR s 0.72, 95% CI s 0.38-1.35, P s 0.301) and overall survival rate (HR s 0.89, 95% CI s 0.39-2.02, P s 0.777).
same time, higher plasma total 25 (OH)D levels in DLBCL patients were significantly associated with better disease progression-free survival (PFS) and not with overall survival rate (OS).
, DLBCL patients with higher levels of 25 (OH) D in total or biological utilization were more sensitive to R-CHOP treatment.
, this study confirms that the bio-utilization level of 25 (OH)D can be used as a new prognostic biomarker in DLBCL patients.
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