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Clin Cancer Res: TIGIT antibody Etigilimab ± nivolumab in the treatment of advanced solid tumors

 Last Update: 2021-12-25
 Source: Internet
 Author: User

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TIGIT is a co-inhibitory receptor for T cell and natural killer cell activity

immunity

This is the first open-label, multi-center, dose-escalation, and expanded phase 1a/b clinical trial in humans, recruiting patients with locally advanced or metastatic solid tumors

Treatment-related side effects

A total of 33 patients were recruited (23 in stage 1a and 10 in stage 1b)

Treatment response of different tumors

In stage 1a, 7 patients (30.

All in all, Etigilimab has acceptable safety.

Etigilimab has acceptable safety.

Original source:

Niharika B.

A Phase 1a / b Open? Label , Dose? Escalation Study of Etigilimab Alone or in Combination with Nivolumab in Patients with Locally Advanced or Metastatic Solid Tumors

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