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Clin Cancer Res: The new BTK inhibitor Zanubrutinib is used to treat relapsed/refractory marginal zone lymphoma

 Last Update: 2021-12-24
 Source: Internet
 Author: User

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Marginal zone lymphoma (MZL) is a rare type of non-Hodgkin's lymphoma, accounting for about 8-12% of non-Hodgkin's lymphoma, and its malignant cells show consistent dependence on B cell receptor signals

Lymphoma

Zanubrutinib is a potential, highly specific, irreversible, new-generation selective Bruton tyrosine kinase inhibitor

Zanubrutinib has shown good anti-tumor activity in Waldenstrom's macroglobulinemia, chronic lymphocytic leukemia /small lymphocytic lymphoma and mantle cell lymphoma

This study is a phase II clinical trial (MAGNOLIA) to evaluate the efficacy and safety of Zanubrutinib in patients with relapsed/refractory (R/R) marginal zone lymphoma

Patients with relapsed/refractory marginal zone lymphoma receive Zanubrutinib 160 mg twice a day until the disease progresses or intolerable toxicity occurs

DOR rate

A total of 68 patients were recruited

The ORR assessed by the independent review committee was 68.

PFS rate

Zanubrutinib treatment is well tolerated, and most of the side effects are grade 1-2

side effects

All in all, Zanubrutinib has shown a high objective remission rate and complete remission rate in patients with relapsed/refractory marginal zone lymphoma, and it has a long-lasting disease control effect and good safety

Zanubrutinib has shown a high objective remission rate and complete remission rate in patients with relapsed/refractory marginal zone lymphoma, and has a long-lasting disease control effect and good safety

Original source:

Stephen Opat, Alessandra Tedeschi, Kim Linton, et al.

The MAGNOLIA Trial: Zanubrutinib, a Next -Generation Bruton Tyrosine Kinase Inhibitor, Demonstrates Safety and Efficacy in Relapsed / Refractory Marginal Zone Lymphoma

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