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Clin Cancer Res: Nivolumab in combination with docetaxel for advanced or recurrent NSCLC

 Last Update: 2022-10-08
 Source: Internet
 Author: User

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The addition of cytotoxic chemotherapy to immune checkpoint inhibitor (ICI) therapy may enhance antitumor effects

Taniguchi et al.

The primary endpoint of the phase III study portion was overall survival (OS), and secondary endpoints included progression-free survival (PF), overall response rate (ORR), and toxicity

Overall survival in both groups

A total of 128 patients (64 in each group) were included in the overall analysis cohort (FAS)

Hematological and gastrointestinal adverse events were more common in arm

In conclusion, the addition of docetaxel to nivolumab significantly prolonged OS and PFS in previously ICI-naïve NSCLC patients despite a slight increase in toxicity

Original source:

Yuri Taniguchi, Tsuneo Shimokawa, Yuichi Takiguchi, et al.

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