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Clin Cancer Res: Long-term prognosis of Tislelizumab in the treatment of relapsed/refractory classic Hodgkin's lymphoma

 Last Update: 2021-12-01
 Source: Internet
 Author: User

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Classical Hodgkin’s lymphoma (cHL) is characterized by the rare malignant Hodgkin’s lymphoma RS (HRS) cells are surrounded by extensive inflammation and immune cell infiltration, such as T cells, macrophages, neutrophils and B cells

Lymphoma Immune Tumor Immune

Tislelizumab is an anti-programmed death protein 1 (anti-PD-1) monoclonal antibody specifically designed to reduce the binding of PD-1 to Fcγ receptors (FcγR)

This article reports the results of a phase II clinical trial of Tislelizumab for the treatment of 70 patients with relapsed/refractory classic Hodgkin’s lymphoma and extended follow-up for 3 years

stem cell

The overall progression-free survival rate of the tested patients

The median follow-up was 33.

The overall remission rate was 87.

Progression-free survival rate of patients with or without a history of autologous stem cell transplantation

97.

Related biomarker analysis showed that FcγRI-expressing macrophages had no significant effect on the remission rate and progression-free survival of Tislelizumab treatment

In summary, through extended follow-up, the study confirmed that Tislelizumab has long-term survival benefits and good safety in patients with relapsed/refractory cHL

Tislelizumab has long-term survival benefits and good safety in patients with relapsed/refractory cHL.

Original source:

Song Yuqin,Gao Quanli,Zhang Huilai et al.

Tislelizumab for relapsed / refractory classical Hodgkin lymphoma : 3-year follow-up and correlative biomarker analysis

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