 Home > Active Ingredient News > Antitumor Therapy > Clin Cancer Res: base excision repair inhibitor TRC102 combined with pemetrexed-cisplatin-radiotherapy standard regimen for the treatment of advanced non-squamous non-small cell lung cancer

Clin Cancer Res: base excision repair inhibitor TRC102 combined with pemetrexed-cisplatin-radiotherapy standard regimen for the treatment of advanced non-squamous non-small cell lung cancer

 Last Update: 2021-12-04
 Source: Internet
 Author: User

Tags

xiaflex side effects

infinitely small

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Lung cancer remains the leading cause of cancer-related deaths worldwide (about 1.

TRC102 is a small molecule base excision repair inhibitor.

This is a phase I clinical trial that evaluated the optimal dose, efficacy and safety of pemetrexed and TRC102 combined with cisplatin radiotherapy in the treatment of stage III non-squamous non-small cell lung cancer (NS-NSCLC)

Progression-free survival

From 2015 to 2019, a total of 15 patients were recruited

3 patients achieved complete remission (20%), 12 patients achieved partial remission (80%), 3 patients achieved complete remission (20%), and 12 patients achieved partial remission (80%) for 6 months The progression-free survival rate was 80%, and the 2-year overall productivity was 83%

Overall survival rate

In summary, the safety and tolerability of pemetrexed combined with TRC102, cisplatin and radiotherapy for non-squamous non-small cell lung cancer are good

The safety and tolerability of pemetrexed combined with TRC102 and cisplatin and radiotherapy for non-squamous cell carcinoma and non-small cell lung cancer are well tolerated Both safety and tolerability are good

Original source:

Biswas Tithi,Dowlati Afshin,Kunos Charles A et al.

Leave a message here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

Crocetin27876-94-4

CAS No.: 27876-94-4

$1-1.1/G FOB

Betulinic acid472-15-1

CAS No.: 472-15-1

$1-1.1/G FOB

1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane 53-19-0

CAS No.: 53-19-0

Pharmacy Grade

$100/KG EXW

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.