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Clin Cancer Res: A novel small molecule thymidylate synthase inhibitor CT900 in the treatment of high-grade serous ovarian cancer

 Last Update: 2022-10-08
 Source: Internet
 Author: User

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CT900 is a novel small molecule thymidylate synthase inhibitor that binds to the α-folate receptor (α-FR), which in turn can be selectively taken up by tumors overexpressing α-FR

The study used a 3+3 dose escalation design

A total of 109 patients were enrolled, 42 in the dose-escalation cohort and 67 in the expansion cohort

In the expansion cohort, the overall response rate (ORR) was 14/64 (21.

In summary, the recommended Phase II dose/scheme is 12 mg/m2/q2Wk

Original source:

Susana Banerjee, Vasiliki Michalarea, Joo Ern Ang, et al.

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