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Platinum drugs are non-specific drugs in the cell cycle, which mainly inhibit the transcription and replication of DNA, thereby promoting tumor cell apoptosis and exerting anti-tumor effec.
Platinum drugs are non-specific drugs in the cell cycle, which mainly inhibit the transcription and replication of DNA, thereby promoting tumor cell apoptosis and exerting anti-tumor effec.
Clinical application of platinum drugs
Clinical application of platinum drugsClinical application of platinum drugs
Adverse reactions and treatment measures
Adverse reactions and treatment measuresAdverse reactions and treatment measures
Configuration and use
Configuration and useConfiguration and use
Drug Interactions
Drug InteractionsDrug Interactions
Combination of platinum drugs
Combination of platinum drugsCombination of platinum drugs
Platinum drugs, as the basic drugs for various tumor treatments, are often used in combination with other anti-tumor drugs for tumor treatme.
Platinum drugs, as the basic drugs for various tumor treatments, are often used in combination with other anti-tumor drugs for tumor treatme.
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Lung cancer: TP regimen (paclitaxel+platinum), DP regimen (docetaxel+platinum), NP regimen (vinorelbine+platinum), GP regimen (gemcitabine+platinum, watch out for platelet toxicity when combined with carboplatin) ) and PC regimen (pemetrexed + platinum);
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Colorectal cancer : FOLFOX regimen (fluorouracil plus folic acid + oxaliplatin) and XELOX regimen (capecitabine + oxaliplatin);
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Gastric cancer : SOX regimen (Segao + oxaliplatin), XELOX regimen (capecitabine + oxaliplatin) and FOLFOX regimen (fluorouracil + folic acid + oxaliplatin);
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Gynecological malignancies : TC regimen (paclitaxel + carboplatin), TP regimen (paclitaxel + cisplatin), PAC regimen (cisplatin + doxorubicin + cyclophosphamide), and PC regimen (cisplatin + cyclophosphamide),e.
Lung cancer: TP regimen (paclitaxel+platinum), DP regimen (docetaxel+platinum), NP regimen (vinorelbine+platinum), GP regimen (gemcitabine+platinum, watch out for platelet toxicity when combined with carboplatin) ) and PC regimen (pemetrexed + platinum);
Lung cancer: TP regimen (paclitaxel+platinum), DP regimen (docetaxel+platinum), NP regimen (vinorelbine+platinum), GP regimen (gemcitabine+platinum, watch out for platelet toxicity when combined with carboplatin) ) and PC regimen (pemetrexed + platinum);
Lung cancer: TP regimen (paclitaxel+platinum), DP regimen (docetaxel+platinum), NP regimen (vinorelbine+platinum), GP regimen (gemcitabine+platinum, watch out for platelet toxicity when combined with carboplatin) ) and PC regimens (pemetrexed + platinum); lung cancer:Colorectal cancer : FOLFOX regimen (fluorouracil plus folic acid + oxaliplatin) and XELOX regimen (capecitabine + oxaliplatin);
Colorectal cancer : FOLFOX regimen (fluorouracil plus folic acid + oxaliplatin) and XELOX regimen (capecitabine + oxaliplatin);
Colorectal cancer : FOLFOX (fluorouracil plus folic acid + oxaliplatin) and XELOX (capecitabine + oxaliplatin); colorectal cancerGastric cancer : SOX regimen (Segao + oxaliplatin), XELOX regimen (capecitabine + oxaliplatin) and FOLFOX regimen (fluorouracil + folic acid + oxaliplatin);
Gastric cancer : SOX regimen (Segao + oxaliplatin), XELOX regimen (capecitabine + oxaliplatin) and FOLFOX regimen (fluorouracil + folic acid + oxaliplatin);
Gastric cancer : SOX regimen (Segao + oxaliplatin), XELOX regimen (capecitabine + oxaliplatin) and FOLFOX regimen (fluorouracil + folic acid + oxaliplatin); gastric cancerGynecological malignancies : TC regimen (paclitaxel + carboplatin), TP regimen (paclitaxel + cisplatin), PAC regimen (cisplatin + doxorubicin + cyclophosphamide), and PC regimen (cisplatin + cyclophosphamide),e.
Gynecological malignancies : TC regimen (paclitaxel + carboplatin), TP regimen (paclitaxel + cisplatin), PAC regimen (cisplatin + doxorubicin + cyclophosphamide), and PC regimen (cisplatin + cyclophosphamide),e.
Gynecological malignancies : TC regimen (paclitaxel + carboplatin), TP regimen (paclitaxel + cisplatin), PAC regimen (cisplatin + doxorubicin + cyclophosphamide), and PC regimen (cisplatin + cyclophosphamide),e.
Affected by drug interactions, attention should be paid to the order of administration when platinum drugs are used in combination with other antitumor dru.
Affected by drug interactions, attention should be paid to the order of administration when platinum drugs are used in combination with other antitumor dru.
Analysis of common clinical problems
Analysis of common clinical problemsAnalysis of common clinical problems
(1) What other methods are available for the prevention and treatment of cisplatin nephrotoxicity besides hydration?
(1) What other methods are available for the prevention and treatment of cisplatin nephrotoxicity besides hydration? (1) What other methods are available for the prevention and treatment of cisplatin nephrotoxicity besides hydration?
① Give patients pre-drinking water or infusion, or use diuretics such as furosemide, or supply a large amount of sodium chloride and perfusion mannitol and other hyperosmotic active substances to reduce the deposition of platinum in the kidneys;
① Give patients pre-drinking water or infusion, or use diuretics such as furosemide, or supply a large amount of sodium chloride and perfusion mannitol and other hyperosmotic active substances to reduce the deposition of platinum in the kidneys;②Add cytoprotective drugs such as amifostine, organic selenium preparations, glutathione, vitamin C, e.
②Add cytoprotective drugs such as amifostine, organic selenium preparations, glutathione, vitamin C, e.
③Adjust the medication ti.
(2) What is the maximum amount of platinum drugs?
(2) What is the maximum amount of platinum drugs? (2) What is the maximum amount of platinum drugs?
There is no clear maximum dose of platinum drugs, and the single dose can refer to the above "Clinical application of platinum drug.
There is no clear maximum dose of platinum drugs, and the single dose can refer to the above "Clinical application of platinum drug.
(3) What is the effect of platinum drugs for thoracic and abdominal perfusion therapy?
(3) What is the effect of platinum drugs for thoracic and abdominal perfusion therapy? (3) What is the effect of platinum drugs for thoracic and abdominal perfusion therapy?
Studies have shown that intrathoracic and abdominal application of platinum drugs combined with recombinant human endostatin , endostatin, recombinant human interleukin-2 and other drugs as well as hyperthermia and other methods can effectively improve the treatment efficiency of pleural effusion and improve the quality of life of patien.
Studies have shown that intrathoracic and abdominal application of platinum drugs combined with recombinant human endostatin , endostatin, recombinant human interleukin-2 and other drugs as well as hyperthermia and other methods can effectively improve the treatment efficiency of pleural effusion and improve the quality of life of patien.
At the same time, there was no increase in treatment-related adverse reactio.
Vascular quality of life
references:
references:[1] Guangdong Pharmaceutical Associati.
Expert consensus on clinical application and adverse reaction management of platinum drugs [.
Pharmacy Today, 2019, 29(9): 361-36
Expert consensus on clinical application and adverse reaction management of platinum drugs [.
Pharmacy Today, 2019, 29(9): 361-36 Management consensus
[2] Feifei Han, Ke Ding, Rui Zhang, et .
Comparison of the efficacy of platinum-based perfusion combined with extracorporeal thoracic and abdominal hyperthermia versus platinum-based body cavity hyperthermia in the treatment of malignant pleural ascites [.
Hainan Medici.
2020, 31(13) : 1683-8
Comparison of the efficacy of platinum-based perfusion combined with extracorporeal thoracic and abdominal hyperthermia versus platinum-based body cavity hyperthermia in the treatment of malignant pleural ascites [.
Hainan Medici.
2020, 31(13) : 1683-8
[3] Liu Jian, Xu Shaodo.
Comparison and prevention of adverse reactions of common platinum antitumor drugs [.
China Pharma.
2013, 24(30):
Comparison and prevention of adverse reactions of common platinum antitumor drugs [.
China Pharma.
2013, 24(30):
[4] Gynecological Oncology Branch of Chinese Medical Associati.
Guidelines for the clinical application of platinum drugs in gynecological tumors [.
Chinese Journal of Medical Frontiers: Electronic Editi.
2021, 13(9):1
Guidelines for the clinical application of platinum drugs in gynecological tumors [.
Frontiers of Chinese Medicine: Electronic Editi.
2021, 13(9):1 Leave a message here
