Circulation: Reducing the intake of branched chain amino acids reduces the risk of thrombosis associated with metabolic syndrome.

!---- branched chain amino acids (BCAAs) are essential nutrients, including leucine, isoleinine, and proline, which can be used as raw materials for energy production as well as regulators for important nutrients and metabolic signalsrecent studies have shown that BCAA breakdown metabolic dysfunction is associated with a risk of cardiovascular diseaseplatelets play an important role in cardiovascular disease, the function of plateletBCA decomposition and metabolism is still unknownstudy tested platelet activity before and after the intake of BCAA by healthy subjectsprotein phosphatase 2Cm specifically to make the branch chain alpha-kealic acid dehydrogenase phosphate, thereby activating BCAA decomposition and metabolismresults show ediped BCAA can significantly promote human platelet activity and arterial thrombosis in micethe strongest promoter of platelet activation in the decomposition metabolism of proline metabolizeant alpha-ketone isoprene and the final oxidation product acryl coenzyme A, suggesting that the decomposition and metabolic pathway of proline/alpha-ketone isoprene plays a major role in BCAA's promotion of platelet activationthe lack ofprotein phosphatase 2Cm significantly inhibited platelet activity caused by anagogenic agentBCAA metabolic pathways may also be involved in the two-way signaling pathway seisquid platelet activation mediated by the integrated alpha IIb beta3BCAAs enhances acrylate at platelettropomodulin-3 K255Tropomodulin-3 K255A mutation eliminates acrylate, thereby reducing BCAAs's promoterofing of integrated cysynmediate cell diffusion, suggesting that The K255 acrylate of Tropomodulin-3 is an important mechanism for BCAA mediated by integrator alpha IIb beta3 to promote platelet activation and thrombosisin platelets from the source of type 2 diabetes, the expression of elevated BCAA levels and the expression of positive regulatory factors in BCAA metabolism was significantly related to the strong activity of plateletsreducing BCAA intake significantly reduced platelet activity in ob/ob miceBCAA decomposition metabolism is an important regulator of platelet activation and is associated with the risk of arterial thrombosistargeting BCAA to break down metabolic pathways or reduce BCAA intake can be used as a new treatment strategy for thrombosis associated with metabolic syndrome.