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Chloroquine/hydroxychloroquine: an inflamma inhibitor in severe COVID-19?

 Last Update: 2022-09-07
 Source: Internet
 Author: User

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Chloroquine (CQ) and hydroxychloroquine (HCQ) are in the aminoquinoline class

Effects of CQ and HCQ on activation of NLRP3 inflammasomes:

In one study, researchers investigated how chloroquine inhibited activation of the NLRP3 inflammasome and protected mice from endotoxin shock

Both artemisinin and hydroxychloroquine have anti-inflammatory and immunomodulatory activities

To study the effects of hydroxychloroquine on NLRP3 inflammatory bodies, serum amyloid A (SAA) was used to stimulate human neutrophils and the secretion

Other drugs that inhibit the NLRP3 inflammatory body:

CQ and HCQ were the most important and certainly the most challenging drugs in the treatment of COVID-19 in the study, but a range of drugs, including statins, antivirals, interferons, antiallergic compounds, and immunomodulators, are currently being used in clinical trials

Taken together, hundreds of clinical trials are being conducted in different countries to investigate potential treatments for

References: Bahadoram M, Keikhaei B, Saeedi-Boroujeni A, Mahmoudian-Sani MR.

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