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The underlying pathophysiological mechanism of the asymmetry of motor symptoms in Parkinson's disease (PD) is currently unclear.
The abnormal neural activity of the basal ganglia neurons is considered to be the basis for the motor symptoms of Parkinson's disease.
In order to explore whether changes in the activity of the subthalamic nucleus (STN) are related to the severity of PD, Professor Zhuang Ping’s team from Xuanwu Hospital of Capital Medical University and Professor Mark of the National Institutes of Health conducted a project to increase the firing rate and β of subthalamic neurons.
Research on the frequency of neuronal activity and whether they are related to the severity of PD.
The results of the study will be announced in the form of a poster abstract at the 2021 American Academy of Neurology Annual Meeting (AAN2021).
Author: Medical NMT NMT Medical Group reported AAN finishing compiler, please do not reprint without authorization.
Research Introduction The researchers recorded the individual STN activity of 30 patients during bilateral deep brain stimulation surgery, and calculated the mean spontaneous firing rate (MSFR), power spectrum analysis and correlation coefficient, and compared the oscillation activity between the hemispheres.
At the same time, the researchers used the third part of the Parkinson's Disease Comprehensive Rating Scale (UPDRS III) to assess the patient's first symptom side, frequently affected side, and symptom prolonged side.
Main findings: ➤The MSFR of STN (41.
3±11.
0 Hz vs 35.
2±10.
0 Hz, p <0.
0001) and the ratio of β neuron activity frequency (51.
3% vs 34.
9%, p <0.
001) were significantly increased on the side of the first symptom .
➤The proportion of tremor frequency oscillatory neurons (34.
9% vs 21.
4%, p <0.
001) was significantly higher on the side of the body with prolonged symptoms. The ratio of β neuron activity frequency was correlated with the bilateral motor retardation/rigidity score (p <0.
05); the ratio of tremor frequency oscillatory neurons was only correlated with the tremor score on the side of the prolonged symptom (p <0.
05).
The study concluded that STN neurons have a higher firing rate, and β-oscillating neurons are more common in the brain on the side with more severe motor retardation.
This result is consistent with the rate theory of PD, which may be caused by the loss of dopaminergic input into the striatum.
The tremor frequency oscillatory neurons are not obvious in the STN on the side of the first symptom, which indicates that the β neuron activity is dominant and the tremor activity cannot be sustained.
Yimaitong compiled from: Increases in subthalamic neuronal firing rate and β frequency neuronal activity in the two hemispheres associated with severity of Parkinson's disease.
! Yimaitong AAN2021 special report Long press the two-dimensional code to follow ☟☟☟ or click "Read the original text" to see more AAN 2021 special related content!
The abnormal neural activity of the basal ganglia neurons is considered to be the basis for the motor symptoms of Parkinson's disease.
In order to explore whether changes in the activity of the subthalamic nucleus (STN) are related to the severity of PD, Professor Zhuang Ping’s team from Xuanwu Hospital of Capital Medical University and Professor Mark of the National Institutes of Health conducted a project to increase the firing rate and β of subthalamic neurons.
Research on the frequency of neuronal activity and whether they are related to the severity of PD.
The results of the study will be announced in the form of a poster abstract at the 2021 American Academy of Neurology Annual Meeting (AAN2021).
Author: Medical NMT NMT Medical Group reported AAN finishing compiler, please do not reprint without authorization.
Research Introduction The researchers recorded the individual STN activity of 30 patients during bilateral deep brain stimulation surgery, and calculated the mean spontaneous firing rate (MSFR), power spectrum analysis and correlation coefficient, and compared the oscillation activity between the hemispheres.
At the same time, the researchers used the third part of the Parkinson's Disease Comprehensive Rating Scale (UPDRS III) to assess the patient's first symptom side, frequently affected side, and symptom prolonged side.
Main findings: ➤The MSFR of STN (41.
3±11.
0 Hz vs 35.
2±10.
0 Hz, p <0.
0001) and the ratio of β neuron activity frequency (51.
3% vs 34.
9%, p <0.
001) were significantly increased on the side of the first symptom .
➤The proportion of tremor frequency oscillatory neurons (34.
9% vs 21.
4%, p <0.
001) was significantly higher on the side of the body with prolonged symptoms. The ratio of β neuron activity frequency was correlated with the bilateral motor retardation/rigidity score (p <0.
05); the ratio of tremor frequency oscillatory neurons was only correlated with the tremor score on the side of the prolonged symptom (p <0.
05).
The study concluded that STN neurons have a higher firing rate, and β-oscillating neurons are more common in the brain on the side with more severe motor retardation.
This result is consistent with the rate theory of PD, which may be caused by the loss of dopaminergic input into the striatum.
The tremor frequency oscillatory neurons are not obvious in the STN on the side of the first symptom, which indicates that the β neuron activity is dominant and the tremor activity cannot be sustained.
Yimaitong compiled from: Increases in subthalamic neuronal firing rate and β frequency neuronal activity in the two hemispheres associated with severity of Parkinson's disease.
! Yimaitong AAN2021 special report Long press the two-dimensional code to follow ☟☟☟ or click "Read the original text" to see more AAN 2021 special related content!
