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The global lifetime prevalence of schizophrenia is about 1%, and it often occurs in young adults, and less than 50% of patients can get a good prognosis.
Integrated omics research provides a feasible method for the identification of risk genes.
Recently, the research team used integrated omics research methods to conduct integrated analysis of association studies and loci from Asian populations, and identified the East Asian population-specific schizophrenia risk susceptibility gene TMEM180.
This study also combined the neural stem cell model to further clarify the potential pathogenic mechanism of this risk gene in the occurrence of schizophrenia.