Chinese scientists have found that cGAS enzymes are at risk of cancer

Tongji University School of Medicine, Tongji University Affiliated Lung Hospital Professor Gobao, Tongji University School of Life Sciences and Technology, Tongji University affiliated with the First Maternal and Infant Health Care Institute Professor Mao Zhiyong research team for the first time systematically explained cGAS completely independent of DNA identification function of the new function of the nuclei, for the intervention of cGAS into the cell nuclei to develop new anti-tumor drugs provide a theoretical basis. The important findings were published online October 25 in the journal nature
.
this morning,
emailed the research team by the journal Xinhua news agency saying that the paper would also be highlighted by
internationally renowned academic journals.
cGAS, called adenosine synthesizer in birds, is a DNA identification subject that was first identified by renowned Chinese scholar Professor Chen Zhijian in the United States and is a milestone in the field of DNA identification and inherent immunity. The synthase promotes the production of type I interferons and immune factors.
cells in the normal growth and metabolism process, affected by a variety of internal and external factors, DNA will always be affected by different forms of damage. DNA double-stranded fracture is one of the most serious forms of DNA damage, it can not be repaired or incorrectly repaired will lead to increased instability of the genome, which in turn will induce chromosomal rearm and loss of genetic information, and eventually will cause cells to die, aging and even lead to the occurrence of tumors.
researchers found that cGAS can be transferred into the nucleus of a cell in the event of DNA damage and recruited to DNA-damaged site, inhibiting the repair of DNA double-stranded fracture damage by interfering with the formation of the PAPR1/Timeless complex, thereby increasing genomic instability and ultimately increasing the risk of tumor formation. The study also found that cGAS inhibits DNA repair as a path that is completely independent of its DNA recognition function.
"cGAS inhibits DNA repair and promotes tumor formation, which is the first time we have discovered a new feature of cGAS internationally." Gobo said that in the past, the understanding of cGAS is focused on the inherent immunity, that is, cGAS as a DNA subject, can identify external pathogenic microorganisms and the body's cytosytes within their own DNA, and activate the immune response, its physiological process research is only in the cytote. However, cGAS, a cancer-promoting feature, has been discovered for the first time, so the results will push cGAS functional research into a whole new field.
important discovery lays the theoretical foundation for the development of new anti-tumor drugs. "CGAS is like a demon in a bottle, " says Gobo, "into the core" is the key point, if we can intervene in cGAS, it has been "off" in the plasma, it will not break into the "cell nucleus" to do bad things. This will be an important target in the development of anti-tumor drugs.
" to do research to broaden thinking and vision, things have yin and yang two aspects, I hope that our discovery can provide researchers with some research ideas and innovative inspiration. Professor Gobo said.Professor
Gobo and Professor Mao Zhiyong are co-authors of this paper, Liu Haipeng, Associate Researcher of Tongji University's Affiliated Lung Hospital, Zhang Haiping, Ph.D., School of Life Sciences and Technology, Tongji University, and Wu Xiangyang, Ph.D. Student, Tongji University School of Medicine, are co-authors of this paper. This research work is funded by the Ministry of Science and Technology, the National Natural Science Foundation of China and the Shanghai Science and Technology Commission, and is supported by research teams such as Fudan University, Xiangya Medical College, and the German Institute of Infectious Biology. (Source: Science Network Huang Xin Huang Aijiao)
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