Science and Technology Daily, Kunming, June 21st (Reporter Zhao Hanbin) The reporter learned from Yunnan University on the 21st that the key laboratory of natural resources medicinal chemistry of the Ministry of Education of the school cooperated with multiple research teams and was online in the international authoritative professional journal "Journal of Medicinal Chemistry".
Liver cancer ranks fourth in the global mortality rate of cancer patients, and ranks second in the mortality rate of cancer patients in China
Existing studies have shown that small ribonucleic acid is involved in the occurrence and development of liver cancer.
Natural Resources, Ministry of Education Key Laboratory of Medicinal Chemistry, Yunnan University Xiaowei Lie Joint Task Force China Ke Xueyuan Chengdu Institute of Biology Research Group Wang Fei, Hu Kaifeng Chengdu University of TCM research group, Professor Zhang Hongbin Yunnan University research group, as well as China Ke Xueyuan Kunming Institute of Botany, SUN Han Dong Academy Research Group, found by a high throughput screening, the biphenyl ring octenes lignans regulates biosynthesis of small RNA in tumor cells, to determine which targets involved in RNA maturation process TRBP small protein, Inhibited the proliferation and metastasis of liver cancer cells
Academician of the Academy of Sciences Further by simplifying the skeleton of biphenyl cyclooctene-like lignans, they designed and synthesized more than 20 derivatives, obtained compound 9 with good activity and specificity, and synthesized compound 9’s biotin probe.
It is reported that the current cooperative research team has applied for a national invention patent in this regard, and is stepping up the follow-up work on the development of new anti-liver cancer drugs for this type of new compound
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