Chinese scholars have revealed the escape mechanism of liver cancer cells in the early stages

The Zhao Bin team of Zhejiang University's Institute of Life Sciences, by establishing animal models of early stage liver cancer, captured for the first time the process by which a single liver tumor starting cell evaded the immune system's "hunt-down" and revealed its principles. This research will have an important impact on further study of the pathogenesis of liver cancer and the development of immunotherapy. The paper was published online
Journal.
" liver cancer morbidity, mortality rate is high, most patients are diagnosed at the end of the cancer in the middle and late stages. In-depth understanding of the pathogenesis of liver cancer, finding new early diagnostic markers, and new therapeutic targets are the focus of liver cancer research. Zhao Bin said.
Zhao Bin's team has established a new type of mouse living liver cell gene editing system, which can "direct" individual normal liver cells to advance cancer, and accurately imitate the development process of liver cancer. "The vast majority of cancers are caused by individual normal soroblast mutations, and new techniques reveal how tumors develop step by step when the first cell carcinoma changes." Zhao Bin introduced.
team found that liver cancer cells survive by secreting a specific cytokine that attracts macrophages to become their "accomplices." According to the researchers, macrophages are important immune cells in the human body that target and devour pathogens, but in the early stages of cancer in single-body cells, macrophages are able to suppress immune cells, and tumor cells successfully evade immune surveillance and avoid removal.
"immune cells with the function of identifying and fighting cancer cells 'surrender' is an important reason for the further development of tumor cells. In the initial stage of liver cancer, the team observed the phenomenon and found the cause. Zhao Bin said.
treatment of tumors is one of the hot topics in cancer research in recent years, and it is the key to develop new methods to re-mobilize the body's immune system to kill or prevent tumors. Zhao Bin said the team will further explore the mechanism of "escape" of liver cancer cells and try to develop an immunodeficiology program
in the early stages of cancer (Source: Xinhua News Agency Zhu Han)