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    Home > Biochemistry News > Biotechnology News > Chinese scholars have revealed new mechanisms by which different subsets of neurons regulate emotion and memory

    Chinese scholars have revealed new mechanisms by which different subsets of neurons regulate emotion and memory

    • Last Update: 2022-10-13
    • Source: Internet
    • Author: User
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    Figure D28K+ and D28K-cholinergic networks that regulate anxiety-like behavior and spatial memory

    With the support of the National Natural Science Foundation of China (Approval No.
    : 31721002), Professor Lu Youming's team at Huazhong University of Science and Technology has made new progress
    in the field of neural mechanisms for cholinergic neurons to regulate emotion and memory 。 The research results were published online in the journal Neuron on September 20, 2022 under the title "Molecularly defined and functionally distinct cholinergic subnetworks" in the journal
    Neuron.

    Cholinergic neurons located in the basal forebrain have advanced functions that regulate learning, memory, attention, and arousal, and recent studies have found that these neurons are heterogeneous, similar to the dopaminergic and norepinephrine systems
    in the brain.
    However, the potential role of cholinergic neuronal heterogeneity in shaping the behavior of individual cholinergic neurons and neuron types remains unknown
    .
    Exploring the coding function of these nerve cells at the single-cell level is at the forefront
    of brain science.
    Professor Lu Youming's research group constructed a variety of recombinant enzyme mutant mice, combined with genetic markers, imaging and recording techniques, and found two cholinergic nerve cell subsets
    of D28K-positive (D28K+) and negative (D28K-).
    By developing and utilizing multiplexing techniques, the anatomy, physiological properties and behavior of D28K+ and D28K- neurons were analyzed, and it was determined that two subsets of cholinergic neurons (D28K+ and D28K-) had unique electrophysiological characteristics, expressed mutually exclusive marker genes, and established different connections with physiologically different neuronal classes in the hippocampus, Two structurally defined and functionally distinct circuits are
    formed.
    Further, using the techniques of acquired and loss-morphing mutations, it was found that these two different types of cholinergic neural circuits regulate anxious behavior and spatial memory
    , respectively.

    This study reveals the different roles of two subsets of cholinergic neurons in regulating anxiety-like behavior and spatial memory, and provides a theoretical basis
    for the subsequent in-depth exploration of the regulatory loops and mechanisms of cholinergic neurons on emotion and memory.

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