Osteoarthritis is a common clinical degenerative disease of the motor system, which manifests as slow-developing joint pain, tenderness, stiffness, joint swelling, restricted movement and joint deformities, etc.
The team first found in clinical specimens and mouse models of patients with osteoarthritis that a large number of synovial fibroblasts had degenerative changes earlier than chondrocytes, and the degree was heavier than chondrocytes; it also found that synovial membranes in osteoarthritis The autophagy level of fibroblasts is significantly reduced, and improving the autophagy level can inhibit the progression of osteoarthritis
This study clarified the mechanism by which the degenerative changes of synovial fibroblasts are involved in the occurrence of osteoarthritis, that is, the methylation of ATG7 mediated by METL3 leads to a decrease in the level of autophagy in synovial fibroblasts, which triggers degenerative changes in the cells.
Figure 1 The degenerative changes of synovial fibroblasts in the process of osteoarthritis and the schematic diagram of the molecular mechanism that mediates the degradation of cartilage matrix
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