Chinese scholars have made new discoveries in the field of natural immunization research of AIDS

12 from the Chinese Academy of Agricultural Sciences Harbin Veterinary Research Institute was informed that the institute's basic immunization team in the field of natural immunity research on AIDS to obtain new discoveries.according to
, serine integration factor (SERINC) is a membrane protein, its family of 5 members, of which SERINC5 and SERINC3 are the latest discovered anti-HIV natural immune molecules, can block the virus infected new cells, thereby reducing the infection of the virus. But little is known about the antiviral activity, in vivo expression, and antiviral agents of members of the SERINC family.
team, Dr. Zhang, discovered that SERINC5 had the highest antiviral activity by systematically comparing five members of the SERINC family, and also detected five different molecular subtypes of the molecule expressed in human cells.
further studies have found that only I subsypes of the five subsypes can be expressed efficiently. Compared to other subsypes, the I subsype has one more transfilm, which enhances protein stability and produces antiviral effectiveness. At the same time, the I subsype is abundant in exocytes and macrophages, indicating its important function in fighting viral infection.
Yonghui, a member of the chinese team, has been working in recent years on the host natural immune molecular mechanism of viral cystic glycoprotein. He told reporters that the latest results reveal a "soft spot" for HIV, providing a new strategy for developing new treatments.
research results have been published online in the international virology well-known professional journal
. (Source: Xinhua News Agency)