Chinese scholars design a nano cage that can be efficiently "detoxifying" and sterilization

Xinhua Hefei, February 5 (Reporter Wu Lan) reporter 4 from the China University of Science and Technology was informed that the university's researchers from the design of a series of nano cages, screening out a highly efficient "detoxification" sterilization of nano cages, experimental results show that the nano cage on a variety of mammalian cells are not toxic.
results were published in the international academic journal Nature Communications on February 2.
the emergence and spread of bacterial resistance seriously threaten the global public health security, how to effectively deal with the problem of bacterial resistance, it is urgent to develop new antimicrobials and antimicrobial therapies.
nanoenzyme is a class of inororated nanoparticles with enzyme-like highly efficient catalytic properties and is considered a new type of antimicrobial agent with broad application prospects, but because reactive oxygen species are unable to distinguish between bacteria and mammalian cells, nanoenzymes lose the selectivity necessary for ideal antimicrobial agents.
In response to this challenge, Yang Lihua of the Hefei National Research Center for Microscale Materials Science of the University of Science and Technology of China, yang Lihua of the School of Chemistry and Materials Science, in collaboration with Xiong Yujie, proposed a strategy for using nanoparticles that can be in-place to catalyticly generate surface adsorption reactive oxygen species to build high-efficiency, low-toxic antimicrobial nanoenzymes.
To test the validity of this strategy, the researchers first designed a series of silver palladium alloy nano cages, from which they screened a nano cage as a model nanoenzyme that efficiently in-place catalyzed the production of surface adsorption reactive oxygen species. The results of in-body antibacterial experiments show that the nano cage can achieve the efficient removal of bacteria, including drug-resistant bacteria (4-16ug/mL can achieve 99.9% bacterial killing efficiency), and after repeated use has not led to the emergence of bacterial resistance.
, the results of in-body cytotoxicity showed that the nano cage was non-toxic to a variety of mammalian cells.
bacterial membrane is a bacterial survival mode that is resistant to many antibiotics, and it is also one of the important reasons for the failure of biomedical implants. Experimental results of medical implants using medical catheters as a model show that the nano cage can not only effectively inhibit the formation of bacterial membranes, but also reduce the inflammatory response of the host infection in animal experiments modeled with catheter implants in mice infected with bacteria.
, this work for the first time proposed a high-efficiency low-toxic antibacterial nanoenzyme construction strategy, is expected to promote the application of biocompatitive nanoenzyme research, and help to deal with the bacterial resistance crisis.