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This method is used to measure the gas permeability of medicinal films or sheets
.
This method includes differential pressure method and coulometric analysis method
.
The coulometric method is only suitable for the detection of oxygen permeation
.
GTR-V3 Gas Transmission Rate Tester The gas transmission rate refers to the gas volume far exceeding the test sample per unit area and unit time under constant temperature and unit pressure difference under stable transmission
.
Usually expressed as the volume value at standard temperature and 1 standard atmospheric pressure, the unit is: cm3 / (mR-24h-0.
1MPa)
.
The gas permeability coefficient refers to the volume of gas permeating the unit thickness of the test sample per unit area and unit time under the condition of constant temperature and unit pressure difference under stable permeation
.
Usually expressed as the volume value under standard temperature and 1 standard atmospheric pressure, the unit is: cm'-cm/mR-24h -0.
1MPa).
Test environment, temperature: 23℃±2℃, relative humidity: 50%±5%
.
The first method of differential pressure method uses medicinal films or sheets to separate the low pressure chamber and the high pressure chamber, the high pressure chamber is filled with a test gas of about 0.
1MPa, and the volume of the low pressure chamber is known
.
After the test sample is sealed, use a vacuum pump to pump the air in the low pressure chamber to a value close to zero
.
Using a manometer to measure the pressure increment AP of the low-pressure chamber can determine the gas amount as a function of time that the test gas passes through the test sample from the high-pressure chamber to the low-pressure chamber, but the initial change of the gas permeation velocity with the time plane should be excluded.
stage
.
The instrument device is a differential pressure gas permeation tester, which mainly includes the following parts
.
The gas-permeable chamber is composed of upper and lower parts.
When the test product is loaded, the upper part is a high-pressure chamber, which is used to store the test gas and is equipped with a gas sampling tube
.
The lower part is a low pressure chamber, which is used to store the gas far past and measure the pressure difference before and after the ventilation process
.
There should be a pressure measuring device in the high and low pressure chambers of the pressure measuring device.
The sensitivity of the pressure measuring device in the high pressure chamber should not be lower than 100Pa, and the sensitivity of the pressure measuring device in the low pressure chamber should not be lower than 5Pa
.
The purity of the test gas should be greater than 99.
5%
.
Unless otherwise specified, select 3 pieces of the test sample of suitable size with uniform thickness and no wrinkles, creases, pinholes and other defects, and mark the side of the test sample facing the test gas proudly.
Place in a desiccator at 2°C for more than 48 hours, measure the thickness of the test sample with a suitable measuring tool, accurate to 0.
001mm, measure at least 5 points for each piece, and take the arithmetic mean
.
Place the instrument on the test
.
In order to eliminate the non-linear stage at the beginning of the test, a 10-minute pre-breathing test should be carried out, and the test should be continued until the change in the pressure difference remains constant within the same time interval, and a stable permeation is achieved
.
T is the test temperature, K; D is the thickness of the test product, cm
.
The test results are expressed as the arithmetic mean of the three samples to be tested.
Except for the samples with high barrier properties [the result of gas transmission is less than or equal to 0.
5cm'/Km2-24h · 0.
1MPa)], the measured value of each sample is the same as that of the samples.
The difference from the average shall not exceed 10% of the average
.
The value of each test sample with high barrier performance shall not be greater than 0.
5cm3/Km2·24h -0.
1MPa)
.
The second method of coulometric analysis (coulometric method) OTR-D3 Oxygen Transmission Rate Tester The test sample divides the breathable chamber into two parts
.
One side of the test product is fed with oxygen and the other with nitrogen carrier gas
.
The oxygen passing through the test product enters the coulometric detector together with the nitrogen carrier gas for chemical reaction and generates a voltage, which is proportional to the amount of oxygen passing through the coulometric detector per unit time
.
Instrumentation Coulometric gas permeation measuring instrument, the instrument mainly includes the following parts
.
The ventilation chamber is composed of two parts, which should be equipped with a temperature measuring device and suitable sealing parts
.
The carrier gas is usually nitrogen or a nitrogen-hydrogen mixture containing a certain ratio of hydrogen
.
The purity of the test gas should not be less than 99.
5%
.
The coulometric detector (coulomb meter) is sensitive to oxygen and has a constant operating characteristic, and is used to measure the amount of oxygen passing through
.
Unless otherwise specified, select 3 test samples of suitable size with uniform thickness, flatness, no wrinkles, creases, pinholes and other defects, and mark the side of the test samples facing the test gas.
Under the environment of ℃±2℃, place it in a desiccator for more than 48 hours, measure the thickness of the test product with a suitable measuring tool, accurate to 0.
001mm, measure at least 5 points, and take the arithmetic mean
.
Put the test sample into the breathable chamber, and then carry out the test.
When the value displayed by the instrument has been stable for a period of time, the test is over
.
The test results are expressed as the arithmetic mean of the three samples to be tested.
Except for the samples with high barrier properties [the result of gas transmission is less than or equal to 0.
5cm3 /(m3-24h · 0.
1MPa)], the measured value of each sample is the same as that of the samples.
The difference from the average shall not exceed 10% of the average
.
The value of each test sample with high barrier performance shall not be greater than 0.
5cm'/(m'-24h·0.
1MPa)
.
.
This method includes differential pressure method and coulometric analysis method
.
The coulometric method is only suitable for the detection of oxygen permeation
.
GTR-V3 Gas Transmission Rate Tester The gas transmission rate refers to the gas volume far exceeding the test sample per unit area and unit time under constant temperature and unit pressure difference under stable transmission
.
Usually expressed as the volume value at standard temperature and 1 standard atmospheric pressure, the unit is: cm3 / (mR-24h-0.
1MPa)
.
The gas permeability coefficient refers to the volume of gas permeating the unit thickness of the test sample per unit area and unit time under the condition of constant temperature and unit pressure difference under stable permeation
.
Usually expressed as the volume value under standard temperature and 1 standard atmospheric pressure, the unit is: cm'-cm/mR-24h -0.
1MPa).
Test environment, temperature: 23℃±2℃, relative humidity: 50%±5%
.
The first method of differential pressure method uses medicinal films or sheets to separate the low pressure chamber and the high pressure chamber, the high pressure chamber is filled with a test gas of about 0.
1MPa, and the volume of the low pressure chamber is known
.
After the test sample is sealed, use a vacuum pump to pump the air in the low pressure chamber to a value close to zero
.
Using a manometer to measure the pressure increment AP of the low-pressure chamber can determine the gas amount as a function of time that the test gas passes through the test sample from the high-pressure chamber to the low-pressure chamber, but the initial change of the gas permeation velocity with the time plane should be excluded.
stage
.
The instrument device is a differential pressure gas permeation tester, which mainly includes the following parts
.
The gas-permeable chamber is composed of upper and lower parts.
When the test product is loaded, the upper part is a high-pressure chamber, which is used to store the test gas and is equipped with a gas sampling tube
.
The lower part is a low pressure chamber, which is used to store the gas far past and measure the pressure difference before and after the ventilation process
.
There should be a pressure measuring device in the high and low pressure chambers of the pressure measuring device.
The sensitivity of the pressure measuring device in the high pressure chamber should not be lower than 100Pa, and the sensitivity of the pressure measuring device in the low pressure chamber should not be lower than 5Pa
.
The purity of the test gas should be greater than 99.
5%
.
Unless otherwise specified, select 3 pieces of the test sample of suitable size with uniform thickness and no wrinkles, creases, pinholes and other defects, and mark the side of the test sample facing the test gas proudly.
Place in a desiccator at 2°C for more than 48 hours, measure the thickness of the test sample with a suitable measuring tool, accurate to 0.
001mm, measure at least 5 points for each piece, and take the arithmetic mean
.
Place the instrument on the test
.
In order to eliminate the non-linear stage at the beginning of the test, a 10-minute pre-breathing test should be carried out, and the test should be continued until the change in the pressure difference remains constant within the same time interval, and a stable permeation is achieved
.
T is the test temperature, K; D is the thickness of the test product, cm
.
The test results are expressed as the arithmetic mean of the three samples to be tested.
Except for the samples with high barrier properties [the result of gas transmission is less than or equal to 0.
5cm'/Km2-24h · 0.
1MPa)], the measured value of each sample is the same as that of the samples.
The difference from the average shall not exceed 10% of the average
.
The value of each test sample with high barrier performance shall not be greater than 0.
5cm3/Km2·24h -0.
1MPa)
.
The second method of coulometric analysis (coulometric method) OTR-D3 Oxygen Transmission Rate Tester The test sample divides the breathable chamber into two parts
.
One side of the test product is fed with oxygen and the other with nitrogen carrier gas
.
The oxygen passing through the test product enters the coulometric detector together with the nitrogen carrier gas for chemical reaction and generates a voltage, which is proportional to the amount of oxygen passing through the coulometric detector per unit time
.
Instrumentation Coulometric gas permeation measuring instrument, the instrument mainly includes the following parts
.
The ventilation chamber is composed of two parts, which should be equipped with a temperature measuring device and suitable sealing parts
.
The carrier gas is usually nitrogen or a nitrogen-hydrogen mixture containing a certain ratio of hydrogen
.
The purity of the test gas should not be less than 99.
5%
.
The coulometric detector (coulomb meter) is sensitive to oxygen and has a constant operating characteristic, and is used to measure the amount of oxygen passing through
.
Unless otherwise specified, select 3 test samples of suitable size with uniform thickness, flatness, no wrinkles, creases, pinholes and other defects, and mark the side of the test samples facing the test gas.
Under the environment of ℃±2℃, place it in a desiccator for more than 48 hours, measure the thickness of the test product with a suitable measuring tool, accurate to 0.
001mm, measure at least 5 points, and take the arithmetic mean
.
Put the test sample into the breathable chamber, and then carry out the test.
When the value displayed by the instrument has been stable for a period of time, the test is over
.
The test results are expressed as the arithmetic mean of the three samples to be tested.
Except for the samples with high barrier properties [the result of gas transmission is less than or equal to 0.
5cm3 /(m3-24h · 0.
1MPa)], the measured value of each sample is the same as that of the samples.
The difference from the average shall not exceed 10% of the average
.
The value of each test sample with high barrier performance shall not be greater than 0.
5cm'/(m'-24h·0.
1MPa)
.
