Chinese medicine gentian is proved to have anti HBV activity

Recently, researchers from Kunming Institute of Botany, Chinese Academy of Sciences found that the ethanol extract of Gentiana scabra, a unique Chinese medicine in Yunnan, has significant anti HBV activity, which initially revealed the anti HBV active components of Gentiana scabra China is a big country with more than 120 million HBV carriers At present, anti HBV drugs such as hepatitis B vaccine, interferon and nucleoside analogues are far from meeting the needs of clinical treatment, so it is urgent to develop new anti HBV drugs with high efficiency, low toxicity and novel mechanism Chinese traditional Chinese medicine is rich in resources In Yunnan Yi and Hani ethnic minority areas, the treatment of acute and chronic hepatitis with green leaf gall has a long history, and the clinical treatment of hepatitis has a definite effect, which has been recorded in successive Chinese Pharmacopoeia Chen Jijun, a researcher of Kunming Institute of Botany, directed Geng Chang'an, a doctoral student, to separate 52 monomers from the active parts of Gentiana, including 26 new compounds In particular, seven new structures of swertide, four dimeric secoiridoid glycosides and a series of new secoiridoid aglycones and glycosides were found for the first time The results showed that 15 compounds had anti HBV activity, especially swertide H-K, which was similar to lamivudine Preliminary studies have shown that its mechanism of action is different from the existing anti HBV drugs Experts believe that this series of studies provide an important chemical and pharmacological basis for expanding the clinical use of Gentiana and finding new anti HBV drugs with novel mechanism of action from traditional Chinese medicine.