Chinese medicine "duanchangcao" can treat pancreatic cancer

Researchers from the University of Minnesota recently reported that the mouse model showed that triptolide, a natural plant product with a long history of use in traditional Chinese medicine, was effective in the treatment of pancreatic cancer Previous studies have shown that pancreatic cancer cells may contain too much HSP70 protein, which can protect cancer cells from death Researchers at the University of Minnesota found that triptolide reduced HSP70 levels in pancreatic cancer cells, which in turn reduced tumor cells in mice Tripterygium wilfordii is a kind of traditional Chinese medicine with a long and widely used history It has been used in the treatment of rheumatoid arthritis and other diseases for hundreds of years It also has a very famous nickname - heartbroken grass Triptolide is one of the main active components of Tripterygium wilfordii In recent years, a large number of in vivo and in vitro studies have proved that the various components extracted from Tripterygium wilfordii have good antitumor effects on a variety of cancers, such as leukemia, breast cancer, pancreatic cancer and lung cancer It is very effective in killing tumor cells According to Xinhua news agency and science and technology daily, pancreatic cancer is a malignant tumor, which is difficult to be found by patients in the early stage When patients in the late stage of pancreatic cancer choose chemotherapy, due to the characteristics of this cancer, the chemotherapy effect is not good, so new treatment methods are urgently needed Researchers found that triptolide, a compound in Tripterygium wilfordii, reduced HSP70 levels in cells and pancreatic cancer cells in mice However, because triptolide is insoluble in water, its effect in mice is not ideal The researchers then processed triptolide to produce a water-soluble, injectable new drug, minocycline, which can be more efficiently transported to pancreatic cancer cells The researchers tested the new drug in mice transplanted with human pancreatic tumors They found that the drug had an excellent effect on killing tumor cells and reducing tumor size Ashok saluya, a professor at the University of Minnesota School of medicine and research director, said that there is no good way to treat pancreatic cancer at present The median survival time of patients after diagnosis is only 6 months, and the current best treatment can only extend the survival time of patients by 6 weeks Their research undoubtedly brings new hope for pancreatic cancer patients The related research report was published in the American Journal of Science Translational Medicine Saluya said that their next step is to carry out toxicity research on new drugs in larger animals and hope to carry out clinical research next year In addition to pancreatic cancer, researchers in the UK this year also found that Tripterygium could be used to treat prostate cancer Researchers from Shanghai Institute of medicine, Chinese Academy of Sciences also conducted in-depth analysis on Tripterygium wilfordii, and found that Tripterygium wilfordii can not only affect some proteins and signal pathways, but also inhibit a wide range of gene transcription, but its mechanism needs to be further clarified Triptolide can also resist cancer triptolide Triptolide comes from the root of Tripterygium wilfordii, which is the main effective component of the rheumatoid drugs Tripterygium wilfordii tablet, Tripterygium wilfordii polyglycoside tablet and other preparations Tripterygium wilfordii is a traditional Chinese medicine, which has been used to treat rheumatoid arthritis and other diseases for hundreds of years Tripterygium wilfordii extract has been used to treat many diseases in China, and its anti-inflammatory, immunosuppressive, contraceptive and anti-tumor effects have been widely praised But it wasn't until 1972 that scientists discovered the mechanism of action - inhibition of cell growth Triptolide, a natural substance, was isolated from Tripterygium wilfordii by Johns Hopkins Medical College in the United States It was found that Tripterygium wilfordii lactone has the function of inhibiting gene control system in cells Based on this, it is expected to develop new anticancer drugs "The extract of this traditional Chinese medicine is used to treat the overall symptoms of patients, and has a high evaluation in resisting inflammation, immunosuppression and improving cancer resistance." Liu junou, Professor of pharmacology and molecular science at Johns Hopkins University, said triptolide can effectively fight cancer, arthritis and rejection of skin transplantation in animal experiments And at low doses, it shows the ability to inhibit all 60 cell lines listed by the National Cancer Research Center, and even kill some cancer cell lines The team systematically tested the effect of triptolide on a variety of gene control proteins, and observed new DNA, RNA and proteins synthesized in cells They treated HeLa cancer cells with triptolide, and compared with untreated cancer cells one hour later, they found that triptolide treated cancer cells took longer to synthesize new proteins and DNA, while RNA regeneration was almost immediately inhibited In fact, Tripterygium wilfordii contains more than 100 kinds of phytochemicals, but the pharmaceutical industry used only the "polyglycosides" before As early as 2006, it has been found that Tripterygium wilfordii contains an excellent natural anti-cancer drug ingredient, Tripterygium wilfordii (also known as "celastrin") In 1988, when Wuhan Botanical Garden of Chinese Academy of Sciences carried out the research project of plant pesticide, researchers found that triptolide was contained in some Celastraceae plants, and then extracted and identified them, and investigated the distribution of these plants in China In 2004, the world's first new anti-cancer drug, proteasome, was launched in the United States In the same year, the Nobel Prize in chemistry was awarded to three scientists for unveiling the secret of death - ubiquitin mediated protein degradation This information provides a new way for Chinese researchers to study the anticancer effect of traditional Chinese medicine After aiming at the research direction of protein degradation, researchers in Wuhan Botanical Garden found that Tripterygium wilfordii heme induced cancer cell death by inhibiting the activity of proteasome In order to verify the anticancer effect of Tripterygium wilfordii, the researchers carried out experiments in nude mice In the experiment, nude mice with transplanted tumors were divided into six groups, and the researchers injected and took triptolide into five groups every day Four months later, the researchers found that Tripterygium wilfordii can inhibit tumor proliferation, with an effective rate of 65% to 93% In 2006, Yuan Xiao, deputy researcher of Wuhan Botanical Garden, Chinese Academy of Sciences, officially announced that his scientific research team, in cooperation with Wayne State University of the United States, had revealed the anti-cancer principle and anti-cancer effect of Tripterygium wilfordii through nude mouse experiment The results were published in the May issue of cancer research, the authoritative international journal of cancer research, which is the first discovery of the anticancer effect of Tripterygium wilfordii The research on Tripterygium wilfordii has become a hot spot in the world Tripterygium wilfordii is an anti-cancer active ingredient The researchers found that the effective rate of Tripterygium wilfordii is 65% to 93%, which is far higher than that of Paclitaxel injection, which is a best-selling drug in the international market What's more exciting is that the newly discovered Tripterygium wilfordii, a new anticancer drug, is non-toxic and harmless to human body It can be used for a long time without damaging the immune system or producing strong side effects It can be said that Tripterygium wilfordii is one of the most ideal natural anticancer drugs discovered by scientists so far Industry insiders believe that Tripterygium wilfordii is expected to become a new best-selling natural anticancer drug in the 21st century, with a market prospect of 3 billion yuan per year At present, Western pharmaceutical researchers are also stepping up their research on Tripterygium wilfordii At present, in addition to Wuhan Botanical Garden of Chinese Academy of Sciences, Shanghai Pharmaceutical Institute of Chinese Academy of Sciences is also cooperating with the National Institutes of health of the United States to carry out pharmacological research on the pharmaceutical components of Tripterygium wilfordii, in order to find better new drugs of Tripterygium wilfordii monomer It can be predicted that Tripterygium wilfordii will become another new plant drug from China after artemisinin and other international best-selling plant drugs Tripterygium wilfordii is also "heartbroken grass" In Jin Yong's novel "the eagles and the chivalrous men", a heartbroken grass confirms the sad and moving love between Yang Guo and Xiao Longnv In fact, "brokenhearted grass" is not a scientific name for a plant, but a general name for a group of plants There are different "heartbroken grass" in different places - those plants that are highly toxic, can cause gastrointestinal reactions such as vomiting, and can kill people seem to have been branded as "heartbroken grass" For example, Stellera of daphneceae, Aconitum of Ranunculaceae and Tripterygium wilfordii of Celastraceae are all members of the "heartbroken grass family" Among these poisons, Tripterygium wilfordii is famous for its Celastraceae Tripterygium wilfordii, also known as rattan, rattan grass, heartbroken grass, mountain arsenic, etc., is a plant of Celastraceae Tripterygium wilfordii is very toxic If you take Tripterygium wilfordii by mistake, you will be poisoned Its manifestations include nausea, vomiting, abdominal pain, diarrhea, and direct damage to the digestive tract, cardiovascular system, nervous system and urinary system Tripterygium wilfordii was born in the shady and wet part of the mountain forest edge It is distributed in the South and southwest of the Yangtze River Basin Roots are picked in autumn, leaves are picked in summer, flowers and fruits are picked in summer and autumn Tripterygium wilfordii is poisonous, especially the skin According to the research, there are two ways for Tripterygium wilfordii to affect human body: one is to stimulate the local gastrointestinal tract; the other is to damage the central nervous system including colliculus, midbrain, medulla oblongata, cerebellum and spinal cord after absorption, and to cause hemorrhage and necrosis of liver and heart.