Chinese is composed of obese gut bacteria, oral polyform bacteria can lose weight.

A new study by a team of Ningguang academicians from Ruijin Hospital affiliated with Shanghai Communication Medical College has revealed for the first timeChinese the composition of obese gut bacteria, and found that a series of intestinal symbiotic bacteria with significant abundance significantly different from normal populations, and oral delivery of polycycobacteria (BT bacteria) can reduce the concentration of serum glutamate in mice, increase the fat decomposition and fat acid oxidation process of fat cells, thereby reducing fat accumulation and achieving weight loss.
June 19, the results were published online in the internationally renowned medical journal Nature Medicine.
, the prevalence of chronic metabolic diseases such as diabetes and cardiovascular diseases is increasing year by year.
and overweight are the main causes of chronic metabolic disorders.
weight loss has become a widely concerned health problem, how to find safe and effective weight loss targets and drugs is also an urgent scientific problem to be solved.
studies have shown that obese people have a structural imbalance in their gut microbiome and a decline in bacterial diversity, but little is known about the bacteria that cause obesity at the germ level.
to this end, Ning Guang and Professor Wang Weiqing, Professor Hong Jie and other researchers focused on the study of intestinal bacteria in obese populations, established large-scale, high-quality obesity-normal-weight population cohorts, and in cooperation with hua university genetic research institute to carry out intestinal microbiome macrogenomic sequencing and in-depth analysis, and through multi-histological analysis to prove that changes in intestinal microbiomes are significantly related to host metabolite levels.
according to the report, BT bacteria have the ability to metabolize glutamate, which is also the main component of MSG in our daily life, and previous Chinese health nutrition surveys have shown that glutamate intake has the risk of promoting overweight in Chinese adults.
To further demonstrate the role of BT bacteria in weight loss benefits, the team also worked with a team of professors of surgery at Ruijin Hospital to analyze changes in intestinal bacterial characteristics before and after surgery in obese patients undergoing weight loss surgery (sleeve gastrectomy), and found that BT bacteria that dropped in the intestines of obese patients increased significantly after weight loss surgery and returned to normal weight levels, while serum glutamate levels decreased significantly after surgery.
the findings suggest that recovery in BT levels may help the weight loss process in obese patients.
" because the dietary characteristics and genetic background of Chinese people are very different from the Western population, there are also large differences in the characteristics of bacteria.
" Ning Guang said, this work undoubtedly provides a new direction and candidate Chinese for the future development of weight loss drugs for women.
it is understood that the research team will work with drug development to promote the use of probiotics in weight loss drugs to slow the obesity epidemic and benefit obese and overweight patients at an early date.
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