22-year data on Chinese population: How much influence does tobacco and alcohol have on the risk of gastric cancer? I'm afraid it will offset other anti-cancer benefits...

Original Title: Chinese Group 22 Data: How Much Impact does Tobacco and Alcohol Affect The Risk of Gastric Cancer? I'm afraid it's going to offset other cancer-fighting benefits... . In China, stomach cancer is the second most high-risk type of cancer. As early as 1995, the team of Peking University Cancer Hospital led a large-scale Shandong intervention test in Linyi County, Shandong Province, which is particularly high. The results of
22 years of follow-up, published in the British Medical Journal (BMJ),
showed that a combination of Pycobacillus therapy, as well as vitamin and garlic supplements, was associated with a long-term decline in the incidence and mortality of stomach cancer.,
lifestyle factors in these high-risk groups affect the prevention of nutritional supplements?
this is the answer to the latest second analysis of the Shandong intervention trial, and the findings, published in jamA Network Open, a sub-journal of the American Medical Association, bring new insights, with
particularly highlighting the effects of alcohol and tobacco.screenshot source:
JAMA Network OpenShandong Intervention Trials included 3,365 residents in Linyi County, a high incidence of stomach cancer, who received two weeks of Helicobacter pylori treatment (amoxicilin and omeprazole) and took vitamin supplements (C, E and selenium) and garlic supplements (extracts and oils) or corresponding placebo controls for 7.3 years.overall, there were 151 new cases of gastric cancer and 94 deaths from stomach cancer during the 22.3-year follow-up period. Previous studies have shown that Helicobacter pylori treatment and vitamin supplements are associated with a 52% and 36% lower risk of stomach cancer, respectively, and garlic supplements have shown a trend of protective effects. Helicobacter pylori treatment, vitamin supplements and garlic supplements were associated with a 38%, 52% and 34% reduction in the risk of death from stomach cancer, respectively.photo source:
123RFthe study focused on lifestyle factors such as smoking, drinking and dietary characteristics.data show that the incidence of stomach cancer in
smokers increased by 72%, and the risk of death doubled, by 101%.
this association was particularly pronounced in people who were positive about Helicobacter pylori, with an 88% and 115 percent increased risk of morbidity and death, respectively. In contrast, while alcohol consumption was also associated with increased risk, it was not statistically significant, and the researchers did not observe a significant effect on cereal, meat and fruit and vegetable intake.further analysis of the effects of lifestyle on the preventive effects of nutritional supplements, and the data present interesting results.
vitamin supplements were more effective at preventing death from stomach cancer in people who had never smoked, with a 65 percent
risk. Similarly, while alcohol consumption alone is not a significant risk factor,
garlic supplements showed preventive effects only in people who never drank alcohol, with a 67 percent
lower risk of death from stomach cancer, while the benefits of garlic supplements were not observed in drinkers, a cross effect that was more pronounced in people who were positive for Helicobacter pylori.
picture source: 123
. RFresearchers continued to broaden the observations to stomach inflammation and precancerous lesions, with 42.9 percent of the subjects in 1995-2003 experiencing progression of stomach lesions, with

intake of fresh fruits and vegetables (81 kg/81 kg/) In people with about 222 g/day
, vitamin supplements also help to slow the lesions and reduce risk by 20%
, while in people with sufficient fruit and vegetable intake, vitamin supplements seem to be somewhat counterproductive, but this effect is only found in people who are not infected with Pyloria. The team ofauthors noted that the analysis is consistent with large-scale prospective studies in Western populations, as well as case control studies conduct ed in Linyi County,
support for smoking is a risk factor for stomach cancer
;previous community intervention trials in the Linyi area have shown that
smoking and drinking are associated with a
of the failure to eradicate Helicobacter pylori. The study further suggests that
tobacco and alcohol may also partially offset the
of nutritional supplements for the prevention benefits of stomach cancer. Based on these findings, the team suggests that in high-risk populations,
gastric cancer prevention strategies need to be combined with lifestyle interventions to maximize the potential beneficial effects of preventive measures.Chart Source: 123RFReferences:
Guo Y, Li Z, Zhang J, et al. (2020). Association SBetween Lifestyle Factors, Vitamin and Garlic Supplementation, and Gastric Cancer Outcomes: A Secondary Analysis of a Random Clinical Trial. JAMA Netw Open, DOI: 10.1001/jamanetworkopen.2020.6628Copyright Description:
this article from the
team of the Pharmaceutical Mingkang WeChat Group,
individuals are welcome to forward to the circle of friends, decline media or institutions without the right to

to reproduce
to other platforms
.
reprinting authorization please reply to "reprint" in the background of the "Medical New Viewpoint" WeChat public number to obtain the reprinting information.for additional cooperation needs, please contact wuxi_media@wuxiapptec.com responsibility Editor:
.