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Chinese Academy of Sciences scholars latest article: the mystery of the origin of CRISPR-Cas "guard RNA"

 Last Update: 2021-10-10
 Source: Internet
 Author: User

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The popular "genetic cut" CRISPR-Cas9 originated from the study of a special immune system in microorganisms (the CRISPR-Cas system) by scientists

In April of this year, the team from the Institute of Microbiology of the Chinese Academy of Sciences to Hua/Li Ming reported in the internationally renowned academic journal "Science" a new type of double RNA-type toxin-antitoxin system CreTA (CRISPR- regulated Toxin-Antitoxin), which answers this important scientific question for the first time and reveals its ingenious molecular mechanism

Recently, the Xiang Hua/Li Ming team reported their latest research progress in the internationally renowned academic journal Nucleic Acids Research, revealing the evolutionary origin of the CreTA system-derived from the highly degraded and alienated mini-CRISPR structure

Figure 1.

(Nucleic Acids Research, doi: 10.

In this latest study, the team also discovered a new type of CreT RNA that produces cytotoxicity by hijacking rare isoleucine tRNA

The above research results were published online in Nucleic Acids Research on September 22, 2021.

Related literature:

Cheng F, Wang R, Yu H, Liu C, Yang J, Xiang H, Li M.

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