China's Ganoderma research enters the era of genomics

The sub-health Intervention Technology Laboratory of Hunan Agricultural University and the cultivation base of the State Key Laboratory of crop germplasm innovation and resource utilization, in combination with Hunan Wanyuan Biotechnology Co., Ltd., recently released the fine genome map of Ganoderma lucidum to the world in the international top scientific journal Public Science Library · comprehensive This is the world's first published complete genome of facultative parasitic edible fungi, marking that the research of medicinal edible fungi in our province has entered the era of genomics and reached the international leading level Today, Professor Liu Dongbo, the chief scientist of the research group, was invited to Beijing to make a special report to the State Administration of traditional Chinese medicine and was ordered to accelerate the promotion and application of this achievement in the field of traditional Chinese medicine Ganoderma lucidum, one of the "nine immortals" collected in the national pharmacopoeia, is a new resource food approved by the Ministry of health of the people's Republic of China It has two-way regulation of immune function, especially for the prevention and treatment of tumor, liver disease, insomnia and aging The published genome size of Ganoderma lucidum is 39.9 trillion, encoding 12080 proteins Based on the whole genome map of Ganoderma lucidum, the scientists first proposed the synthetic way of triterpenoids, the main functional component of Ganoderma lucidum, which is expected to uncover the mystery of the price and efficacy of Ganoderma lucidum from genomics At the same time, the scientists obtained 422 cellulose degrading enzyme genes and 37 lignin degrading enzyme genes, which showed the unique advantages of Ganoderma lucidum in degrading straw, straw and other fibrous raw materials to produce new energy, and found a new way for the development of biomass energy It is located in the sub-health Intervention Technology Laboratory of the State Administration of traditional Chinese medicine of Hunan Agricultural University It is committed to the use of genomics, metabonomics, proteomics and transcriptomics and other systematic biological technologies to carry out the research on the basis of sub-health materials group and the key technologies for the protection and sustainable utilization of Chinese herbal resources In the past two years, we have completed the whole genome research of Ganoderma lucidum and the metabonomics research of drug severe allergy, both of which are at the international leading level In order to explore the "gene lineage" of genuine medicinal materials and the "functional group" of wild and cultivated medicinal materials, the laboratory is using Ganoderma lucidum as the "model medicinal fungus" to carry out the research of re sequencing and transcriptome, and set about to build the "functional gene pool" of Chinese Medicine with international patent, so as to explore a new way for the modernization and internationalization of Chinese medicine.