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| The Chinese University of Science and Technology Research Group uses new nanomedicine technology to provide new solutions for the treatment of pancreatic cancer |
China News Service, Hefei, March 14 (Reporter Wu Lan) Pancreatic cancer is extremely lethal.
The reporter learned from the University of Science and Technology of China on the 14th that the Yang Lihua research group of the school proposed for the first time an acid-sensitive nanoparticle formed by the self-assembly of a single rupture macromolecule, which can simultaneously achieve the dual goals of pancreatic cancer matrix remodeling and cancer cell removal.
Related results were recently published in the American Chemical Society "Applied Materials and Interface".
Yang Lihua’s research group proposed to develop 100% acid-sensitive nanoparticles that are composed of membrane-breaking macromolecules, can maintain a long circulation time in the blood, and can dissociate under the unique slightly acidic pH stimulation of the tumor microenvironment as a new treatment for pancreatic cancer.
Both the three-dimensional cell sphere and tumor-bearing mouse model experiments showed that after intravenous administration of the nanoparticles, the expression of extracellular matrix in the pancreatic cancer microenvironment was significantly reduced, and the originally dense pancreatic tumor tissue became permeable and improved The delivery efficiency of nanoparticles in tumor tissues did not cause tumor metastasis.
