Chest: Modified pathological T staging of NSCLC with visceral pleural infiltration (VPI): analysis of 1055 cases of NSCLC with swelling ≤3cm

Visceral pleural infiltration (VPI) is considered to be a poor prognostic factor for patients with non-small cell lung cancer ( NSCLC )
.
The positivity of VPI increases the T1 stage to T2, so that the IA stage becomes IB

.

Visceral pleural infiltration (VPI) is considered to be a poor prognostic factor for patients with non-small cell lung cancer ( NSCLC )

A total of 1055 patients with primary NSCLC with tumor size ≤ 3 cm were included in this study

.

A total of 1055 patients with primary NSCLC with tumor size ≤ 3 cm were included in this study

824 patients were diagnosed with VPI as PL0, 133 patients were diagnosed as PL1, and 98 patients were diagnosed as PL2

The median follow-up time for the overall population was 49.

When PL1 and PL2 patients were combined, the DFS and OS of these patients were worse than those of PL0 patients (P<0.

Three sets of DFS and OS differences

Three sets of DFS and OS differences

When only patients with negative lymph nodes are considered, the data again shows that the long-term survival of patients with PL0 and PL1 is similar (DFS: P=0.

468; OS: P=0.

When only patients with negative lymph nodes are considered, the data again shows that the long-term survival of patients with PL0 and PL1 is similar (DFS: P=0.

Differences in DFS and OS between the three groups of lymph node negative and positive stratification

Differences in DFS and OS between the three groups of lymph node negative and positive stratification

Multivariate analysis found that PL2 (hazard ratio [HR], 1.

692; 95% CI, 1.

Multivariate analysis found that PL2 (hazard ratio [HR], 1.

Multi-factor analysis of DFS and OS

Multi-factor analysis of DFS and OS

Further analysis, when only N0 patients were included, the study showed that PL2 and poor cell differentiation were independent prognostic factors for poor DFS and OS

.

Further analysis, when only N0 patients were included, the study showed that PL2 and poor cell differentiation were independent prognostic factors for poor DFS and OS
.

Multivariate analysis of DFS and OS in N0 patients

Multivariate analysis of DFS and OS in N0 patients Multivariate analysis of DFS and OS in N0 patients

In summary, studies have shown that for patients with NSCLC ≤ 3 cm, PL1 should still be defined as T1 stage rather than T2 stage
.
At the same time, postoperative adjuvant chemotherapy should be avoided in NSCLC patients with negative lymph nodes, ≤3 cm, and PL1
.

In summary, studies have shown that for patients with NSCLC ≤ 3 cm, PL1 should still be defined as T1 stage rather than T2 stage
.
At the same time, postoperative adjuvant chemotherapy should be avoided in NSCLC patients with negative lymph nodes, ≤3 cm, and PL1
.
Studies have shown that for patients with NSCLC ≤ 3 cm, PL1 should still be defined as T1 stage rather than T2 stage
.
At the same time, postoperative adjuvant chemotherapy should be avoided in NSCLC patients with negative lymph nodes, ≤3 cm, and PL1
.
Studies have shown that for patients with NSCLC ≤ 3 cm, PL1 should still be defined as T1 stage rather than T2 stage
.
At the same time, postoperative adjuvant chemotherapy should be avoided in NSCLC patients with negative lymph nodes, ≤3 cm, and PL1
.

Original source:

Original source:

Liang RB, Li P, Li BT, Jin JT, Rusch VW, Jones DR, Wu YL, Liu Q, Yang J, Yang MZ, Li S, Long H, Fu JH, Zhang LJ, Lin P, Rong TH, Hou X , Lin SX, Yang HX.
Modification of Pathologic T Classification for Non-small Cell Lung Cancer With Visceral Pleural Invasion: Data From 1,055 Cases of Cancers ≤ 3 cm.
Chest.
2021 Aug;160(2):754-764.
doi: 10.
1016/j.
chest.
2021.
03.
022.
Epub 2021 Mar 18.
PMID: 33745993; PMCID: PMC8449009.

Liang RB, Li P, Li BT, Jin JT, Rusch VW, Jones DR, Wu YL, Liu Q, Yang J, Yang MZ, Li S, Long H, Fu JH, Zhang LJ, Lin P, Rong TH, Hou X , Lin SX, Yang HX.
Modification of Pathologic T Classification for Non-small Cell Lung Cancer With Visceral Pleural Invasion: Data From 1,055 Cases of Cancers ≤ 3 cm.
Chest.
2021 Aug;160(2):754-764.
doi: 10.
1016/j.
chest.
2021.
03.
022.
Epub 2021 Mar 18.
PMID: 33745993; PMCID: PMC8449009.
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